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10.1183/16000617.0317-2020 http://scihub22266oqcxt.onion/10.1183/16000617.0317-2020 33536264!8522998!33536264     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Respir+Rev 2021 ; 30 (159): ä Nephropedia Template TP {{tp|p=33536264|t=2021. Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research |pdf=|usr=}}{{33536264}} gab.com Text Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research JO: Eur Respir Rev http://www.kidney.de/pget.php?&tw=1&pmid=33536264 #FOAvip Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be triggered by a wide range of insults and remains associated with a high mortality of around 40%. The search for targeted treatment for ARDS has been disappointing, possibly due to the enormous heterogeneity within the syndrome. In this perspective from the European Respiratory Society research seminar on "Precision medicine in ARDS", we will summarise the current evidence for heterogeneity, explore the evidence in favour of precision medicine and provide a roadmap for further research in ARDS. There is evident variation in the presentation of ARDS on three distinct levels: 1) aetiological; 2) physiological and 3) biological, which leads us to the conclusion that there is no typical ARDS. The lack of a common presentation implies that intervention studies in patients with ARDS need to be phenotype aware and apply a precision medicine approach in order to avoid the lack of success in therapeutic trials that we faced in recent decades. Deeper phenotyping and integrative analysis of the sources of variation might result in identification of additional treatable traits that represent specific pathobiological mechanisms, or so-called endotypes. Twit Text FOAVip Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research ????Eur Respir Rev http://www.kidney.de/pget.php?&tw=1&pmid=33536264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33536264 #FOAvip English Wikipedia <ref>{{Cite pmid|33536264}}</ref> Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research #MMPMID33536264 Bos LDJ; Artigas A; Constantin JM; Hagens LA; Heijnen N; Laffey JG; Meyer N; Papazian L; Pisani L; Schultz MJ; Shankar-Hari M; Smit MR; Summers C; Ware LB; Scala R; Calfee CS Eur Respir Rev 2021[Mar]; 30 (159): ä PMID33536264show ga Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be triggered by a wide range of insults and remains associated with a high mortality of around 40%. The search for targeted treatment for ARDS has been disappointing, possibly due to the enormous heterogeneity within the syndrome. In this perspective from the European Respiratory Society research seminar on "Precision medicine in ARDS", we will summarise the current evidence for heterogeneity, explore the evidence in favour of precision medicine and provide a roadmap for further research in ARDS. There is evident variation in the presentation of ARDS on three distinct levels: 1) aetiological; 2) physiological and 3) biological, which leads us to the conclusion that there is no typical ARDS. The lack of a common presentation implies that intervention studies in patients with ARDS need to be phenotype aware and apply a precision medicine approach in order to avoid the lack of success in therapeutic trials that we faced in recent decades. Deeper phenotyping and integrative analysis of the sources of variation might result in identification of additional treatable traits that represent specific pathobiological mechanisms, or so-called endotypes. |*Respiratory Distress Syndrome/diagnosis/therapy[MESH] |Humans[MESH] |Phenotype[MESH]Precision medicine in acute respiratory distress syndrome: workshop re(epmc).pdf DeepDyve Pubget Overpricing