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10.1126/science.abf6950 http://scihub22266oqcxt.onion/10.1126/science.abf6950 33536258!7971772!33536258     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 371 (6534): 1139-1142 Nephropedia Template TP {{tp|p=33536258|t=2021. Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape |pdf=|usr=}}{{33536258}} gab.com Text Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33536258 #FOAvip Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human populations. The descendants of these viruses have adapted to the human host and evolved to evade immune pressure. Coronaviruses acquire substitutions more slowly than other RNA viruses. In the spike glycoprotein, we found that recurrent deletions overcome this slow substitution rate. Deletion variants arise in diverse genetic and geographic backgrounds, transmit efficiently, and are present in novel lineages, including those of current global concern. They frequently occupy recurrent deletion regions (RDRs), which map to defined antibody epitopes. Deletions in RDRs confer resistance to neutralizing antibodies. By altering stretches of amino acids, deletions appear to accelerate SARS-CoV-2 antigenic evolution and may, more generally, drive adaptive evolution. Twit Text FOAVip Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33536258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33536258 #FOAvip English Wikipedia <ref>{{Cite pmid|33536258}}</ref> Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape #MMPMID33536258 McCarthy KR; Rennick LJ; Nambulli S; Robinson-McCarthy LR; Bain WG; Haidar G; Duprex WP Science 2021[Mar]; 371 (6534): 1139-1142 PMID33536258show ga Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human populations. The descendants of these viruses have adapted to the human host and evolved to evade immune pressure. Coronaviruses acquire substitutions more slowly than other RNA viruses. In the spike glycoprotein, we found that recurrent deletions overcome this slow substitution rate. Deletion variants arise in diverse genetic and geographic backgrounds, transmit efficiently, and are present in novel lineages, including those of current global concern. They frequently occupy recurrent deletion regions (RDRs), which map to defined antibody epitopes. Deletions in RDRs confer resistance to neutralizing antibodies. By altering stretches of amino acids, deletions appear to accelerate SARS-CoV-2 antigenic evolution and may, more generally, drive adaptive evolution. |*Immune Evasion[MESH] |Amino Acid Sequence[MESH] |Amino Acid Substitution[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |Antigens, Viral/chemistry/*genetics[MESH] |COVID-19/*virology[MESH] |Evolution, Molecular[MESH] |Genetic Drift[MESH] |Humans[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*genetics[MESH] |Sequence Deletion[MESH]Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibod(epmc).pdf DeepDyve Pubget Overpricing