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10.1186/s12920-021-00887-1 http://scihub22266oqcxt.onion/10.1186/s12920-021-00887-1 33536004!7856619!33536004     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med+Genomics 2021 ; 14 (1): 38 Nephropedia Template TP {{tp|p=33536004|t=2021. Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study |pdf=|usr=}}{{33536004}} gab.com Text Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study JO: BMC Med Genomics http://www.kidney.de/pget.php?&tw=1&pmid=33536004 #FOAvip BACKGROUND: Lifestyle factors including obesity and smoking are suggested to be correlated with increased risk of COVID-19 severe illness or related death. However, whether these relationships are causal is not well known; neither for the relationships between COVID-19 severe illness and other common lifestyle factors, such as physical activity and alcohol consumption. METHODS: Genome-wide significant genetic variants associated with body mass index (BMI), lifetime smoking, physical activity and alcohol consumption identified by large-scale genome-wide association studies (GWAS) of up to 941,280 individuals were selected as instrumental variables. Summary statistics of the genetic variants on severe illness of COVID-19 were obtained from GWAS analyses of up to 6492 cases and 1,012,809 controls. Two-sample Mendelian randomisation analyses were conducted. RESULTS: Both per-standard deviation (SD) increase in genetically predicted BMI and lifetime smoking were associated with about two-fold increased risks of severe respiratory COVID-19 and COVID-19 hospitalization (all P < 0.05). Per-SD increase in genetically predicted physical activity was associated with decreased risks of severe respiratory COVID-19 (odds ratio [OR] = 0.19; 95% confidence interval [CI], 0.05, 0.74; P = 0.02), but not with COVID-19 hospitalization (OR = 0.44; 95% CI 0.18, 1.07; P = 0.07). No evidence of association was found for genetically predicted alcohol consumption. Similar results were found across robust Mendelian randomisation methods. CONCLUSIONS: Evidence is found that BMI and smoking causally increase and physical activity might causally decrease the risk of COVID-19 severe illness. This study highlights the importance of maintaining a healthy lifestyle in protecting from COVID-19 severe illness and its public health value in fighting against COVID-19 pandemic. Twit Text FOAVip Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study ????BMC Med Genomics http://www.kidney.de/pget.php?&tw=1&pmid=33536004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33536004 #FOAvip English Wikipedia <ref>{{Cite pmid|33536004}}</ref> Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study #MMPMID33536004 Li S; Hua X BMC Med Genomics 2021[Feb]; 14 (1): 38 PMID33536004show ga BACKGROUND: Lifestyle factors including obesity and smoking are suggested to be correlated with increased risk of COVID-19 severe illness or related death. However, whether these relationships are causal is not well known; neither for the relationships between COVID-19 severe illness and other common lifestyle factors, such as physical activity and alcohol consumption. METHODS: Genome-wide significant genetic variants associated with body mass index (BMI), lifetime smoking, physical activity and alcohol consumption identified by large-scale genome-wide association studies (GWAS) of up to 941,280 individuals were selected as instrumental variables. Summary statistics of the genetic variants on severe illness of COVID-19 were obtained from GWAS analyses of up to 6492 cases and 1,012,809 controls. Two-sample Mendelian randomisation analyses were conducted. RESULTS: Both per-standard deviation (SD) increase in genetically predicted BMI and lifetime smoking were associated with about two-fold increased risks of severe respiratory COVID-19 and COVID-19 hospitalization (all P < 0.05). Per-SD increase in genetically predicted physical activity was associated with decreased risks of severe respiratory COVID-19 (odds ratio [OR] = 0.19; 95% confidence interval [CI], 0.05, 0.74; P = 0.02), but not with COVID-19 hospitalization (OR = 0.44; 95% CI 0.18, 1.07; P = 0.07). No evidence of association was found for genetically predicted alcohol consumption. Similar results were found across robust Mendelian randomisation methods. CONCLUSIONS: Evidence is found that BMI and smoking causally increase and physical activity might causally decrease the risk of COVID-19 severe illness. This study highlights the importance of maintaining a healthy lifestyle in protecting from COVID-19 severe illness and its public health value in fighting against COVID-19 pandemic. |*Life Style[MESH] |Alcohol Drinking[MESH] |Body Mass Index[MESH] |COVID-19/*diagnosis/genetics/virology[MESH] |Exercise[MESH] |Genetic Variation[MESH] |Genome-Wide Association Study[MESH] |Humans[MESH] |Linkage Disequilibrium[MESH] |Mendelian Randomization Analysis/*methods[MESH] |Odds Ratio[MESH] |Risk Factors[MESH] |SARS-CoV-2/isolation & purification[MESH] |Severity of Illness Index[MESH]Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian ran(epmc).pdf DeepDyve Pubget Overpricing