Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1084/jem.20201387

http://scihub22266oqcxt.onion/10.1084/jem.20201387
suck pdf from google scholar
33533916!7849819!33533916
unlimited free pdf from europmc33533916    free
PDF from PMC    free
html from PMC    free

Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33533916&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215

suck abstract from ncbi


Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid33533916      J+Exp+Med 2021 ; 218 (4): ä
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4 #MMPMID33533916
  • Onodi F; Bonnet-Madin L; Meertens L; Karpf L; Poirot J; Zhang SY; Picard C; Puel A; Jouanguy E; Zhang Q; Le Goff J; Molina JM; Delaugerre C; Casanova JL; Amara A; Soumelis V
  • J Exp Med 2021[Apr]; 218 (4): ä PMID33533916show ga
  • Several studies have analyzed antiviral immune pathways in late-stage severe COVID-19. However, the initial steps of SARS-CoV-2 antiviral immunity are poorly understood. Here we have isolated primary SARS-CoV-2 viral strains and studied their interaction with human plasmacytoid predendritic cells (pDCs), a key player in antiviral immunity. We show that pDCs are not productively infected by SARS-CoV-2. However, they efficiently diversified into activated P1-, P2-, and P3-pDC effector subsets in response to viral stimulation. They expressed CD80, CD86, CCR7, and OX40 ligand at levels similar to influenza virus-induced activation. They rapidly produced high levels of interferon-alpha, interferon-lambda1, IL-6, IP-10, and IL-8. All major aspects of SARS-CoV-2-induced pDC activation were inhibited by hydroxychloroquine. Mechanistically, SARS-CoV-2-induced pDC activation critically depended on IRAK4 and UNC93B1, as established using pDC from genetically deficient patients. Overall, our data indicate that human pDC are efficiently activated by SARS-CoV-2 particles and may thus contribute to type I IFN-dependent immunity against SARS-CoV-2 infection.
  • |Biomarkers[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*immunology/*metabolism/virology[MESH]
  • |Cell Plasticity/*immunology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Dendritic Cells/*immunology/*metabolism/virology[MESH]
  • |Host-Pathogen Interactions/immunology[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/pharmacology/therapeutic use[MESH]
  • |Immunomodulation[MESH]
  • |Immunophenotyping[MESH]
  • |Inflammation Mediators/metabolism[MESH]
  • |Interferon Lambda[MESH]
  • |Interferon Type I/metabolism[MESH]
  • |Interferons/metabolism[MESH]
  • |Interleukin-1 Receptor-Associated Kinases/*metabolism[MESH]
  • |Membrane Transport Proteins/*metabolism[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box