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10.1084/jem.20202515

http://scihub22266oqcxt.onion/10.1084/jem.20202515
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33533915!7845919!33533915
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suck abstract from ncbi

pmid33533915      J+Exp+Med 2021 ; 218 (4): ä
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  • Persistent cellular immunity to SARS-CoV-2 infection #MMPMID33533915
  • Breton G; Mendoza P; Hagglof T; Oliveira TY; Schaefer-Babajew D; Gaebler C; Turroja M; Hurley A; Caskey M; Nussenzweig MC
  • J Exp Med 2021[Apr]; 218 (4): ä PMID33533915show ga
  • SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen-specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4+ and CD8+ memory T cells, including expression of activation/exhaustion markers, and cell division.
  • |*Immunity, Cellular[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antigens, Viral/immunology[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/*immunology/*virology[MESH]
  • |Female[MESH]
  • |Host-Pathogen Interactions/*immunology[MESH]
  • |Humans[MESH]
  • |Immunophenotyping[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |T-Cell Antigen Receptor Specificity[MESH]
  • |T-Lymphocyte Subsets/immunology/metabolism[MESH]


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