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10.36233/0507-4088-2020-65-3-167-175

http://scihub22266oqcxt.onion/10.36233/0507-4088-2020-65-3-167-175
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33533219!ä!33533219

suck abstract from ncbi


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pmid33533219      Vopr+Virusol 2020 ; 65 (3): 167-175
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  • The use of viral RNA polymerase inhibitors in combination with a fusion inhibitor in the treatment of patients with COVID-19: hypothesis #MMPMID33533219
  • Gaisenok OV
  • Vopr Virusol 2020[Jul]; 65 (3): 167-175 PMID33533219show ga
  • This review article considers the possibilities of combined antiviral therapy in the treatment of patients with COVID-19, based on the analysis of the mechanism of action of known antiviral drugs in the framework of the medical hypothesis. The potential effectiveness of the joint use of viral RNA polymerase inhibitors and a fusion inhibitor in this pathology is discussed. The review discusses the main representatives of these groups of drugs - ribavirin, riamilovir, umifenovir, favipiravir. The efficacy and safety profile of these drugs was analyzed, including the experience of their use in clinical trials conducted during the COVID-19 pandemic, as well as earlier work performed during the SARS and MERS epidemics.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/epidemiology[MESH]
  • |*Pandemics[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Enzyme Inhibitors/*therapeutic use[MESH]
  • |Humans[MESH]
  • |RNA-Dependent RNA Polymerase/*antagonists & inhibitors/metabolism[MESH]


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