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10.1007/s13311-021-01008-7

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suck abstract from ncbi


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pmid33533012      Neurotherapeutics 2021 ; 18 (1): 244-251
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  • Potential Risks and Benefits of Multiple Sclerosis Immune Therapies in the COVID-19 Era: Clinical and Immunological Perspectives #MMPMID33533012
  • Bhise V; Dhib-Jalbut S
  • Neurotherapeutics 2021[Jan]; 18 (1): 244-251 PMID33533012show ga
  • Coronavirus SARS-CoV2 has emerged as one of the greatest infectious disease health challenges in a century. Patients with multiple sclerosis (MS) have a particular vulnerability to infections through their use of immunosuppressive disease-modifying therapies (DMTs). Specific DMTs pose particular risk based on their mechanisms of action (MOA). As a result, patients require individualized approaches to starting new treatments and continuation of therapy. Additionally, vaccinations must be considered carefully, and individuals on long-term B cell-depleting therapies may have diminished immune responses to vaccination, based on preserved T cells and diminished but present antibody titers to influenza vaccines. We review the immunology behind these treatments and their impact on COVID-19, as well as the current recommendations for best practices for use of DMTs in patients with MS.
  • |*COVID-19[MESH]
  • |*Pandemics[MESH]
  • |Antirheumatic Agents/adverse effects[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/therapeutic use[MESH]
  • |Immunotherapy/*adverse effects/*methods[MESH]
  • |Multiple Sclerosis/*complications/*therapy[MESH]


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