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10.1007/s11548-021-02317-0

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33532975!7854027!33532975
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suck abstract from ncbi


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pmid33532975      Int+J+Comput+Assist+Radiol+Surg 2021 ; 16 (3): 423-434
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  • Six artificial intelligence paradigms for tissue characterisation and classification of non-COVID-19 pneumonia against COVID-19 pneumonia in computed tomography lungs #MMPMID33532975
  • Saba L; Agarwal M; Patrick A; Puvvula A; Gupta SK; Carriero A; Laird JR; Kitas GD; Johri AM; Balestrieri A; Falaschi Z; Pasche A; Viswanathan V; El-Baz A; Alam I; Jain A; Naidu S; Oberleitner R; Khanna NN; Bit A; Fatemi M; Alizad A; Suri JS
  • Int J Comput Assist Radiol Surg 2021[Mar]; 16 (3): 423-434 PMID33532975show ga
  • BACKGROUND: COVID-19 pandemic has currently no vaccines. Thus, the only feasible solution for prevention relies on the detection of COVID-19-positive cases through quick and accurate testing. Since artificial intelligence (AI) offers the powerful mechanism to automatically extract the tissue features and characterise the disease, we therefore hypothesise that AI-based strategies can provide quick detection and classification, especially for radiological computed tomography (CT) lung scans. METHODOLOGY: Six models, two traditional machine learning (ML)-based (k-NN and RF), two transfer learning (TL)-based (VGG19 and InceptionV3), and the last two were our custom-designed deep learning (DL) models (CNN and iCNN), were developed for classification between COVID pneumonia (CoP) and non-COVID pneumonia (NCoP). K10 cross-validation (90% training: 10% testing) protocol on an Italian cohort of 100 CoP and 30 NCoP patients was used for performance evaluation and bispectrum analysis for CT lung characterisation. RESULTS: Using K10 protocol, our results showed the accuracy in the order of DL > TL > ML, ranging the six accuracies for k-NN, RF, VGG19, IV3, CNN, iCNN as 74.58 +/- 2.44%, 96.84 +/- 2.6, 94.84 +/- 2.85%, 99.53 +/- 0.75%, 99.53 +/- 1.05%, and 99.69 +/- 0.66%, respectively. The corresponding AUCs were 0.74, 0.94, 0.96, 0.99, 0.99, and 0.99 (p-values < 0.0001), respectively. Our Bispectrum-based characterisation system suggested CoP can be separated against NCoP using AI models. COVID risk severity stratification also showed a high correlation of 0.7270 (p < 0.0001) with clinical scores such as ground-glass opacities (GGO), further validating our AI models. CONCLUSIONS: We prove our hypothesis by demonstrating that all the six AI models successfully classified CoP against NCoP due to the strong presence of contrasting features such as ground-glass opacities (GGO), consolidations, and pleural effusion in CoP patients. Further, our online system takes < 2 s for inference.
  • |*Artificial Intelligence[MESH]
  • |COVID-19/*diagnostic imaging[MESH]
  • |Deep Learning[MESH]
  • |Diagnosis, Differential[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia/*diagnostic imaging[MESH]
  • |SARS-CoV-2[MESH]


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