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10.1007/s00228-021-03087-z

http://scihub22266oqcxt.onion/10.1007/s00228-021-03087-z
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33532896!7853160!33532896
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suck abstract from ncbi


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pmid33532896      Eur+J+Clin+Pharmacol 2021 ; 77 (8): 1089-1094
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  • The effect of tocilizumab on mortality in hospitalized patients with COVID-19: a meta-analysis of randomized controlled trials #MMPMID33532896
  • Kow CS; Hasan SS
  • Eur J Clin Pharmacol 2021[Aug]; 77 (8): 1089-1094 PMID33532896show ga
  • OBJECTIVE: We aimed to perform a meta-analysis of randomized controlled trials (RCTs) to summarize the overall effect of tocilizumab on the risk of mortality among patients with coronavirus disease 2019 (COVID-19). METHODS: We systematically searched PubMed, Cochrane Central Register of Controlled Trials, Google Scholar, and medRxiv (preprint repository) databases (up to 7 January 2021). Pooled effect sizes with 95% confidence interval (CI) were generated using random-effects and inverse variance heterogeneity models. The risk of bias of the included RCTs was appraised using version 2 of the Cochrane risk-of-bias tool for randomized trials. RESULTS: Six RCTs were included: two trials with an overall low risk of bias and four trials had some concerns regarding the overall risk of bias. Our meta-analysis did not find significant mortality benefits with the use of tocilizumab among patients with COVID-19 relative to non-use of tocilizumab (pooled hazard ratio = 0.83; 95% CI 0.66-1.05, n = 2,057). Interestingly, the estimated effect of tocilizumab on the composite endpoint of requirement for mechanical ventilation and/or all-cause mortality indicated clinical benefits, with some evidence against our model hypothesis of no significant effect at the current sample size (pooled hazard ratio = 0.62; 95% CI 0.42-0.91, n = 749). CONCLUSION: Despite no clear mortality benefits in hospitalized patients with COVID-19, tocilizumab appears to reduce the likelihood of progression to mechanical ventilation.
  • |*COVID-19 Drug Treatment[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19/mortality[MESH]
  • |Disease Progression[MESH]
  • |Humans[MESH]
  • |Inpatients[MESH]
  • |Randomized Controlled Trials as Topic[MESH]


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