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10.1101/2021.01.21.21249203 http://scihub22266oqcxt.onion/10.1101/2021.01.21.21249203 33532784!7852234!33532784     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       medRxiv 2021 ; ä (ä): ä Nephropedia Template TP {{tp|p=33532784|t=2021. SARS-CoV-2 recruits a haem metabolite to evade antibody immunity |pdf=|usr=}}{{33532784}} gab.com Text SARS-CoV-2 recruits a haem metabolite to evade antibody immunity JO: medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33532784 #FOAvip The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies. We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity. Using cryo-electron microscopy and X-ray crystallography we mapped the tetrapyrrole interaction pocket to a deep cleft on the spike N-terminal domain (NTD). At physiological concentrations, biliverdin significantly dampened the reactivity of SARS-CoV-2 spike with immune sera and inhibited a subset of neutralizing antibodies. Access to the tetrapyrrole-sensitive epitope is gated by a flexible loop on the distal face of the NTD. Accompanied by profound conformational changes in the NTD, antibody binding requires relocation of the gating loop, which folds into the cleft vacated by the metabolite. Our results indicate that the virus co-opts the haem metabolite for the evasion of humoral immunity via allosteric shielding of a sensitive epitope and demonstrate the remarkable structural plasticity of the NTD. Twit Text FOAVip SARS-CoV-2 recruits a haem metabolite to evade antibody immunity ????medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33532784 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33532784 #FOAvip English Wikipedia <ref>{{Cite pmid|33532784}}</ref> SARS-CoV-2 recruits a haem metabolite to evade antibody immunity #MMPMID33532784 Rosa A; Pye VE; Graham C; Muir L; Seow J; Ng KW; Cook NJ; Rees-Spear C; Parker E; Dos Santos MS; Rosadas C; Susana A; Rhys H; Nans A; Masino L; Roustan C; Christodoulou E; Ulferts R; Wrobel A; Short CE; Fertleman M; Sanders RW; Heaney J; Spyer M; Kjaer S; Riddell A; Malim MH; Beale R; MacRae JI; Taylor GP; Nastouli E; van Gils MJ; Rosenthal PB; Pizzato M; McClure MO; Tedder RS; Kassiotis G; McCoy LE; Doores KJ; Cherepanov P medRxiv 2021[Jan]; ä (ä): ä PMID33532784show ga The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies. We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity. Using cryo-electron microscopy and X-ray crystallography we mapped the tetrapyrrole interaction pocket to a deep cleft on the spike N-terminal domain (NTD). At physiological concentrations, biliverdin significantly dampened the reactivity of SARS-CoV-2 spike with immune sera and inhibited a subset of neutralizing antibodies. Access to the tetrapyrrole-sensitive epitope is gated by a flexible loop on the distal face of the NTD. Accompanied by profound conformational changes in the NTD, antibody binding requires relocation of the gating loop, which folds into the cleft vacated by the metabolite. Our results indicate that the virus co-opts the haem metabolite for the evasion of humoral immunity via allosteric shielding of a sensitive epitope and demonstrate the remarkable structural plasticity of the NTD. äSARS-CoV-2 recruits a haem metabolite to evade antibody immunity (epmc).pdf DeepDyve Pubget Overpricing