Sensitivity of SARS-CoV-2 to different temperatures #MMPMID33532706
Lv Q; Liu M; Qi F; Gong S; Zhou S; Zhan S; Bao L
Animal Model Exp Med 2020[Dec]; 3 (4): 316-318 PMID33532706show ga
This study was designed to investigate the sensitivity of SARS-CoV-2 to different temperatures, to provide basic data and a scientific basis for the control of COVID-19 epidemic. The virus was dispersed in 1 mL basal DMEM medium at a final concentration of 10(3.2) TCID(50)/mL and then incubated at 4, 22, 30, 35, 37, 38, 39 and 40 degrees C for up to 5 days. The infectivity of residual virus was titrated using the Vero E6 cell line. The results showed that the virus remained viable for 5 days at 4 degrees C, and for 1 day only at 22 and 30 degrees C. We found that the infectivity of the virus was completely lost after less than 12 hours at 37, 38 and 39 degrees C, while at 40 degrees C, the inactivation time of the virus was rapidly reduced to 6 hours. We show that SARS-CoV-2 is sensitive to heat, is more stable at lower temperatures than higher temperature, remains viable for longer at lower temperatures, and loses viability rapidly at higher temperatures.