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10.4103/japtr.JAPTR_89_20

http://scihub22266oqcxt.onion/10.4103/japtr.JAPTR_89_20
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33532356!7832181!33532356
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suck abstract from ncbi


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pmid33532356      J+Adv+Pharm+Technol+Res 2021 ; 12 (1): 57-60
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  • A single dose of in situ gel formulation of antimalarial drug chloroquine phosphate as a sustained prophylactic candidate for COVID-19 #MMPMID33532356
  • Zelai NT
  • J Adv Pharm Technol Res 2021[Jan]; 12 (1): 57-60 PMID33532356show ga
  • In the ongoing COVID-19 outbreak, a prophylactic drug is strongly needed to stop the spread of this disease. Chloroquine (CQ) has been proposed as a prophylactic for individuals who are likely to be exposed to the virus. This study aimed to study the ability of CQ to act as a prophylactic treatment for susceptible people. The pharmacokinetic profiles of in situ gel and free CQ phosphate were determined using high-performance liquid chromatography. The effects of both formulations were examined on both liver and kidney functions. CQ levels were sustained in the plasma of both free and in situ gel-treated groups. Thus, our study shows that the in situ gel of CQ provides sustained release of CQ that is given only as a single dose. However, it should be used cautiously in patients with liver or kidney dysfunction.
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