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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Science 2021 ; 371 (6536): ä Nephropedia Template TP
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Age groups that sustain resurging COVID-19 epidemics in the United States #MMPMID33531384
Monod M; Blenkinsop A; Xi X; Hebert D; Bershan S; Tietze S; Baguelin M; Bradley VC; Chen Y; Coupland H; Filippi S; Ish-Horowicz J; McManus M; Mellan T; Gandy A; Hutchinson M; Unwin HJT; van Elsland SL; Vollmer MAC; Weber S; Zhu H; Bezancon A; Ferguson NM; Mishra S; Flaxman S; Bhatt S; Ratmann O
Science 2021[Mar]; 371 (6536): ä PMID33531384show ga
After initial declines, in mid-2020 a resurgence in transmission of novel coronavirus disease (COVID-19) occurred in the United States and Europe. As efforts to control COVID-19 disease are reintensified, understanding the age demographics driving transmission and how these affect the loosening of interventions is crucial. We analyze aggregated, age-specific mobility trends from more than 10 million individuals in the United States and link these mechanistically to age-specific COVID-19 mortality data. We estimate that as of October 2020, individuals aged 20 to 49 are the only age groups sustaining resurgent SARS-CoV-2 transmission with reproduction numbers well above one and that at least 65 of 100 COVID-19 infections originate from individuals aged 20 to 49 in the United States. Targeting interventions-including transmission-blocking vaccines-to adults aged 20 to 49 is an important consideration in halting resurgent epidemics and preventing COVID-19-attributable deaths.