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10.1016/j.humimm.2020.12.010 http://scihub22266oqcxt.onion/10.1016/j.humimm.2020.12.010 33531264!7762835!33531264     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Immunol 2021 ; 82 (3): 170-176 Nephropedia Template TP {{tp|p=33531264|t=2021. Dynamic changes in monocytes subsets in COVID-19 patients |pdf=|usr=}}{{33531264}} gab.com Text Dynamic changes in monocytes subsets in COVID-19 patients JO: Hum Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33531264 #FOAvip BACKGROUND: Coronavirus disease 2019 (COVID-19) is affecting the whole world and threatening human health. We aim to investigate the immunological characteristics of monocytes in critical patients with COVID-19. METHODS: The number and immune status of monocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals. RESULTS: In critical patients with COVID-19, the absolute number of total monocytes and CD16(-) monocytes was significantly decreased but CD16(+) pro-inflammatory monocytes was increased compared to healthy controls. Antigen presentation potential of monocytes, as measured by HLA-DR expression, was suppressed, while their inflammatory phenotype (CD38 expression) was enhanced. Cytokine levels showed sustained increases in critical patients. And the levels of IL-6 were positively correlated with CD16(+) monocytes number. IL-6 and IL-10 levels were negatively correlated with HLA-DR expression of monocytes. During the recovery of COVID-19 patients, the count and immune status of monocyte subsets were restored by degrees. HLA-DR(+) monocytes possessed good sensitivity and specificity for predicting the incidence of critical patients with COVID-19. CONCLUSIONS: In critical patients with COVID-19, decline in number and HLA-DR expression of monocytes might lead to decreased antigen presentation potential and thus immunosuppression, while increased CD16(+) pro-inflammatory monocytes might mediate hyperinflammation. HLA-DR(+) monocytes might be a meaningful assisted indicator to predict the incidence of critical patients with COVID-19. Twit Text FOAVip Dynamic changes in monocytes subsets in COVID-19 patients ????Hum Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33531264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33531264 #FOAvip English Wikipedia <ref>{{Cite pmid|33531264}}</ref> Dynamic changes in monocytes subsets in COVID-19 patients #MMPMID33531264 Qin S; Jiang Y; Wei X; Liu X; Guan J; Chen Y; Lu H; Qian J; Wang Z; Lin X Hum Immunol 2021[Mar]; 82 (3): 170-176 PMID33531264show ga BACKGROUND: Coronavirus disease 2019 (COVID-19) is affecting the whole world and threatening human health. We aim to investigate the immunological characteristics of monocytes in critical patients with COVID-19. METHODS: The number and immune status of monocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals. RESULTS: In critical patients with COVID-19, the absolute number of total monocytes and CD16(-) monocytes was significantly decreased but CD16(+) pro-inflammatory monocytes was increased compared to healthy controls. Antigen presentation potential of monocytes, as measured by HLA-DR expression, was suppressed, while their inflammatory phenotype (CD38 expression) was enhanced. Cytokine levels showed sustained increases in critical patients. And the levels of IL-6 were positively correlated with CD16(+) monocytes number. IL-6 and IL-10 levels were negatively correlated with HLA-DR expression of monocytes. During the recovery of COVID-19 patients, the count and immune status of monocyte subsets were restored by degrees. HLA-DR(+) monocytes possessed good sensitivity and specificity for predicting the incidence of critical patients with COVID-19. CONCLUSIONS: In critical patients with COVID-19, decline in number and HLA-DR expression of monocytes might lead to decreased antigen presentation potential and thus immunosuppression, while increased CD16(+) pro-inflammatory monocytes might mediate hyperinflammation. HLA-DR(+) monocytes might be a meaningful assisted indicator to predict the incidence of critical patients with COVID-19. |ADP-ribosyl Cyclase 1/immunology[MESH] |Aged[MESH] |Antigen Presentation[MESH] |COVID-19/blood/*immunology[MESH] |Case-Control Studies[MESH] |Cytokines/immunology[MESH] |Female[MESH] |Flow Cytometry[MESH] |HLA-DR Antigens/immunology[MESH] |Humans[MESH] |Inflammation/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/*immunology[MESH] |Phenotype[MESH]Dynamic changes in monocytes subsets in COVID-19 patients (epmc).pdf DeepDyve Pubget Overpricing