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10.2174/1573409917666210202092646

http://scihub22266oqcxt.onion/10.2174/1573409917666210202092646
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33530913!ä!33530913

suck abstract from ncbi


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pmid33530913      Curr+Comput+Aided+Drug+Des 2021 ; 17 (7): 936-945
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  • Cluster Analysis of Coronavirus Sequences using Computational Sequence Descriptors: With Applications to SARS, MERS and SARS-CoV-2 (CoVID-19) #MMPMID33530913
  • Vracko M; Basak SC; Dey T; Nandy A
  • Curr Comput Aided Drug Des 2021[]; 17 (7): 936-945 PMID33530913show ga
  • INTRODUCTION: Coronaviruses comprise a group of enveloped, positive-sense single-stranded RNA viruses that infect humans as well as a wide range of animals. The study was performed on a set of 573 sequences belonging to SARS, MERS and SARS-CoV-2 (CoVID-19) viruses. The sequences were represented with alignment-free sequence descriptors and analyzed with different chemometric methods: Euclidean/Mahalanobis distances, principal component analysis and self-organizing maps (Kohonen networks). We report the cluster structures of the data. The sequences are well-clustered regarding the type of virus; however, some of them show the tendency to belong to more than one virus type. BACKGROUND: This is a study of 573 genome sequences belonging to SARS, MERS and SARS-- CoV-2 (CoVID-19) coronaviruses. OBJECTIVES: The aim was to compare the virus sequences, which originate from different places around the world. METHODS: The study used alignment free sequence descriptors for the representation of sequences and chemometric methods for analyzing clusters. RESULTS: Majority of genome sequences are clustered with respect to the virus type, but some of them are outliers. CONCLUSION: We indicate 71 sequences, which tend to belong to more than one cluster.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Animals[MESH]
  • |Cluster Analysis[MESH]


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