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10.1098/rsif.2020.0683 http://scihub22266oqcxt.onion/10.1098/rsif.2020.0683 33530857!8086877!33530857     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+R+Soc+Interface 2021 ; 18 (175): 20200683 Nephropedia Template TP {{tp|p=33530857|t=2021. Trajectory of individual immunity and vaccination required for SARS-CoV-2 community immunity: a conceptual investigation |pdf=|usr=}}{{33530857}} gab.com Text Trajectory of individual immunity and vaccination required for SARS-CoV-2 community immunity: a conceptual investigation JO: J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=33530857 #FOAvip SARS-CoV-2 is an international public health emergency; high transmissibility and morbidity and mortality can result in the virus overwhelming health systems. Combinations of social distancing, and test, trace, and isolate strategies can reduce the number of new infections per infected individual below 1, thus driving declines in case numbers, but may be both challenging and costly. These interventions must also be maintained until development and (now likely) mass deployment of a vaccine (or therapeutics), since otherwise, many susceptible individuals are still at risk of infection. We use a simple analytical model to explore how low levels of infection, combined with vaccination, determine the trajectory to community immunity. Understanding the repercussions of the biological characteristics of the viral life cycle in this scenario is of considerable importance. We provide a simple description of this process by modelling the scenario where the effective reproduction number [Formula: see text] is maintained at 1. Since the additional complexity imposed by the strength and duration of transmission-blocking immunity is not yet clear, we use our framework to probe the impact of these uncertainties. Through intuitive analytical relations, we explore how the necessary magnitude of vaccination rates and mitigation efforts depends crucially on the durations of natural and vaccinal immunity. We also show that our framework can encompass seasonality or preexisting immunity due to epidemic dynamics prior to strong mitigation measures. Taken together, our simple conceptual model illustrates the importance of individual and vaccinal immunity for community immunity, and that the quantification of individuals immunized against SARS-CoV-2 is paramount. Twit Text FOAVip Trajectory of individual immunity and vaccination required for SARS-CoV-2 community immunity: a conceptual investigation ????J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=33530857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33530857 #FOAvip English Wikipedia <ref>{{Cite pmid|33530857}}</ref> Trajectory of individual immunity and vaccination required for SARS-CoV-2 community immunity: a conceptual investigation #MMPMID33530857 Saad-Roy CM; Levin SA; Metcalf CJE; Grenfell BT J R Soc Interface 2021[Feb]; 18 (175): 20200683 PMID33530857show ga SARS-CoV-2 is an international public health emergency; high transmissibility and morbidity and mortality can result in the virus overwhelming health systems. Combinations of social distancing, and test, trace, and isolate strategies can reduce the number of new infections per infected individual below 1, thus driving declines in case numbers, but may be both challenging and costly. These interventions must also be maintained until development and (now likely) mass deployment of a vaccine (or therapeutics), since otherwise, many susceptible individuals are still at risk of infection. We use a simple analytical model to explore how low levels of infection, combined with vaccination, determine the trajectory to community immunity. Understanding the repercussions of the biological characteristics of the viral life cycle in this scenario is of considerable importance. We provide a simple description of this process by modelling the scenario where the effective reproduction number [Formula: see text] is maintained at 1. Since the additional complexity imposed by the strength and duration of transmission-blocking immunity is not yet clear, we use our framework to probe the impact of these uncertainties. Through intuitive analytical relations, we explore how the necessary magnitude of vaccination rates and mitigation efforts depends crucially on the durations of natural and vaccinal immunity. We also show that our framework can encompass seasonality or preexisting immunity due to epidemic dynamics prior to strong mitigation measures. Taken together, our simple conceptual model illustrates the importance of individual and vaccinal immunity for community immunity, and that the quantification of individuals immunized against SARS-CoV-2 is paramount. |*Immunity, Herd[MESH] |*Vaccination[MESH] |Basic Reproduction Number[MESH] |COVID-19 Vaccines[MESH] |COVID-19/*immunology/*prevention & control[MESH] |Epidemics[MESH] |Humans[MESH] |Immune System[MESH] |Physical Distancing[MESH] |Public Health[MESH]Trajectory of individual immunity and vaccination required for SARS-Co(epmc).pdf DeepDyve Pubget Overpricing