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10.3390/molecules26030632 http://scihub22266oqcxt.onion/10.3390/molecules26030632 33530467!7865633!33530467     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2021 ; 26 (3): ä Nephropedia Template TP {{tp|p=33530467|t=2021. Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets |pdf=|usr=}}{{33530467}} gab.com Text Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33530467 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified in China as the etiologic agent of the recent COVID-19 pandemic outbreak. Due to its high transmissibility, this virus quickly spread throughout the world, causing considerable health issues. The scientific community exerted noteworthy efforts to obtain therapeutic solutions for COVID-19, and new scientific networks were constituted. No certified drugs to efficiently inhibit the virus were identified, and the development of de-novo medicines requires approximately ten years of research. Therefore, the repurposing of natural products could be an effective strategy to handle SARS-CoV-2 infection. This review aims to update on current status of the natural occurring compounds recognizing SARS-CoV-2 druggable targets. Among the clinical trials actually recruited, some natural compounds are ongoing to examine their potential role to prevent and to treat the COVID-19 infection. Many natural scaffolds, including alkaloids, terpenes, flavonoids, and benzoquinones, were investigated by in-silico, in-vitro, and in-vivo approaches. Despite the large data set obtained by a computational approach, experimental evidences in most cases are not available. To fill this gap, further efforts to validate these results are required. We believe that an accurate investigation of naturally occurring compounds may provide insights for the potential treatment of COVID-19 patients. Twit Text FOAVip Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33530467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33530467 #FOAvip English Wikipedia <ref>{{Cite pmid|33530467}}</ref> Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets #MMPMID33530467 Romeo I; Mesiti F; Lupia A; Alcaro S Molecules 2021[Jan]; 26 (3): ä PMID33530467show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified in China as the etiologic agent of the recent COVID-19 pandemic outbreak. Due to its high transmissibility, this virus quickly spread throughout the world, causing considerable health issues. The scientific community exerted noteworthy efforts to obtain therapeutic solutions for COVID-19, and new scientific networks were constituted. No certified drugs to efficiently inhibit the virus were identified, and the development of de-novo medicines requires approximately ten years of research. Therefore, the repurposing of natural products could be an effective strategy to handle SARS-CoV-2 infection. This review aims to update on current status of the natural occurring compounds recognizing SARS-CoV-2 druggable targets. Among the clinical trials actually recruited, some natural compounds are ongoing to examine their potential role to prevent and to treat the COVID-19 infection. Many natural scaffolds, including alkaloids, terpenes, flavonoids, and benzoquinones, were investigated by in-silico, in-vitro, and in-vivo approaches. Despite the large data set obtained by a computational approach, experimental evidences in most cases are not available. To fill this gap, further efforts to validate these results are required. We believe that an accurate investigation of naturally occurring compounds may provide insights for the potential treatment of COVID-19 patients. |*Antiviral Agents/chemistry/therapeutic use[MESH] |*COVID-19 Drug Treatment[MESH] |*Drug Delivery Systems[MESH] |*SARS-CoV-2/chemistry/metabolism[MESH] |COVID-19/epidemiology/metabolism[MESH] |Humans[MESH]Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing