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10.3390/ijms22031203 http://scihub22266oqcxt.onion/10.3390/ijms22031203 33530458!7865494!33530458     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (3): ä Nephropedia Template TP {{tp|p=33530458|t=2021. Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery |pdf=|usr=}}{{33530458}} gab.com Text Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33530458 #FOAvip A high-throughput drug screen identifies potentially promising therapeutics for clinical trials. However, limitations that persist in current disease modeling with limited physiological relevancy of human patients skew drug responses, hamper translation of clinical efficacy, and contribute to high clinical attritions. The emergence of induced pluripotent stem cell (iPSC) technology revolutionizes the paradigm of drug discovery. In particular, iPSC-based three-dimensional (3D) tissue engineering that appears as a promising vehicle of in vitro disease modeling provides more sophisticated tissue architectures and micro-environmental cues than a traditional two-dimensional (2D) culture. Here we discuss 3D based organoids/spheroids that construct the advanced modeling with evolved structural complexity, which propels drug discovery by exhibiting more human specific and diverse pathologies that are not perceived in 2D or animal models. We will then focus on various central nerve system (CNS) disease modeling using human iPSCs, leading to uncovering disease pathogenesis that guides the development of therapeutic strategies. Finally, we will address new opportunities of iPSC-assisted drug discovery with multi-disciplinary approaches from bioengineering to Omics technology. Despite technological challenges, iPSC-derived cytoarchitectures through interactions of diverse cell types mimic patients' CNS and serve as a platform for therapeutic development and personalized precision medicine. Twit Text FOAVip Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33530458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33530458 #FOAvip English Wikipedia <ref>{{Cite pmid|33530458}}</ref> Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery #MMPMID33530458 Qian L; Tcw J Int J Mol Sci 2021[Jan]; 22 (3): ä PMID33530458show ga A high-throughput drug screen identifies potentially promising therapeutics for clinical trials. However, limitations that persist in current disease modeling with limited physiological relevancy of human patients skew drug responses, hamper translation of clinical efficacy, and contribute to high clinical attritions. The emergence of induced pluripotent stem cell (iPSC) technology revolutionizes the paradigm of drug discovery. In particular, iPSC-based three-dimensional (3D) tissue engineering that appears as a promising vehicle of in vitro disease modeling provides more sophisticated tissue architectures and micro-environmental cues than a traditional two-dimensional (2D) culture. Here we discuss 3D based organoids/spheroids that construct the advanced modeling with evolved structural complexity, which propels drug discovery by exhibiting more human specific and diverse pathologies that are not perceived in 2D or animal models. We will then focus on various central nerve system (CNS) disease modeling using human iPSCs, leading to uncovering disease pathogenesis that guides the development of therapeutic strategies. Finally, we will address new opportunities of iPSC-assisted drug discovery with multi-disciplinary approaches from bioengineering to Omics technology. Despite technological challenges, iPSC-derived cytoarchitectures through interactions of diverse cell types mimic patients' CNS and serve as a platform for therapeutic development and personalized precision medicine. |Animals[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/pathology[MESH] |Central Nervous System Diseases/*drug therapy/pathology[MESH] |Drug Discovery/instrumentation/*methods[MESH] |Drug Evaluation, Preclinical/instrumentation/methods[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/*cytology/*drug effects/pathology[MESH] |Lab-On-A-Chip Devices[MESH] |Organoids/cytology/drug effects/pathology[MESH] |Tissue Engineering/instrumentation/*methods[MESH]Human iPSC-Based Modeling of Central Nerve System Disorders for Drug D(epmc).pdf DeepDyve Pubget Overpricing