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10.1097/MD.0000000000024524

http://scihub22266oqcxt.onion/10.1097/MD.0000000000024524
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33530280!7850706!33530280
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suck abstract from ncbi

pmid33530280
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  • Co-infection in patients with hypoxemic pneumonia due to COVID-19 in Reunion Island #MMPMID33530280
  • Allou N; Larsen K; Dubernet A; Traversier N; Masse L; Foch E; Bruneau L; Maillot A; Andre M; Lagrange-Xelot M; Allyn J; Thomas V; Coolen-Allou N
  • Medicine (Baltimore) 2021[Jan]; 100 (4): e24524 PMID33530280show ga
  • ABSTRACT: This study aimed to evaluate the incidence of co-infection with different types of pathogens in patients with hypoxemic pneumonia due to coronavirus disease 2019 (COVID-19) in Reunion Island.This observational study using a prospectively collected database of hypoxemic pneumonia due to COVID-19 cases was conducted at Felix Guyon University Hospital in Reunion Island, France.Between 18 March 2020 and 15 April 2020, 156 patients were admitted to our hospital for COVID-19. A total of 36 patients had hypoxemic pneumonia (23.1%) due to COVID-19. Thirty of these cases (83.3%) were imported by travelers returning mainly from metropolitan France and Spain. Patients were screened for co-infection with other pathogens at admission: 31 (86.1%) by multiplex polymerase chain reaction (PCR) and 16 (44.4%) by cytobacteriological examination of sputum culture. Five patients (13.9%) were found to have co-infection: 1 with influenza virus A H1N1 (pdm09) associated with Branhamella catarrhalis, 1 with Streptococcus pneumoniae associated with Haemophilus influenzae, 1 with Human Coronavirus 229E, 1 with Rhinovirus, and 1 with methicillin-susceptible Staphylococcus aureus. Patients with co-infection had higher D-dimer levels than those without co-infection (1.36 [1.34-2.36] mug/mL vs 0.63 [0.51-1.12] mug/mL, P = .05).The incidence of co-infection in our cohort was higher than expected (13.9%). Three co-infections (with influenza virus A(H1N1) pdm09, Streptococcus pneumoniae, and Staphylococcus aureus) required specific treatment. Patients with hypoxemic pneumonia due to COVID-19 should be screened for co-infection using respiratory cultures or multiplex PCR. Whilst our study has a number of limitations, the results from our study suggest that in the absence of screening, patients should be commenced on treatment for co-infection in the presence of an elevated D-dimer.
  • |Adult[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Coinfection/*epidemiology[MESH]
  • |Female[MESH]
  • |France/epidemiology[MESH]
  • |Humans[MESH]
  • |Hypoxia[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pneumonia/*epidemiology/*microbiology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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  • suck abstract from ncbi

    e24524 4.100 2021