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10.1093/gerona/glab035 http://scihub22266oqcxt.onion/10.1093/gerona/glab035 33530099!7929197!33530099     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gerontol+A+Biol+Sci+Med+Sci 2021 ; 76 (8): e147-e154 Nephropedia Template TP {{tp|p=33530099|t=2021. Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19 |pdf=|usr=}}{{33530099}} gab.com Text Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19 JO: J Gerontol A Biol Sci Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=33530099 #FOAvip BACKGROUND: The genetic locus 3p21.31 has been associated with severe coronavirus disease 2019 (COVID-19), but the underlying pathophysiological mechanism is unknown. METHODS: To identify intermediate traits associated with the 3p21.31 locus, we first performed a phenome-wide association study (PheWAS) with 923 phenotypes in 310 999 European individuals from the UK Biobank. For genes potentially regulated by the COVID-19 risk variant, we examined associations between their expression and the polygenic score (PGS) of 1263 complex traits in a meta-analysis of 31 684 blood samples. For the prioritized blood cell traits, we tested their associations with age and sex in the same UK Biobank sample. RESULTS: Our PheWAS highlighted multiple blood cell traits to be associated with the COVID-19 risk variant, including monocyte count and percentage (p = 1.07 x 10-8, 4.09 x 10-13), eosinophil count and percentage (p = 5.73 x 10-3, 2.20 x 10-3), and neutrophil percentage (p = 3.23 x 10-3). The PGS analysis revealed positive associations between the expression of candidate genes and genetically predicted counts of specific blood cells: CCR3 with eosinophil and basophil (p = 5.73 x 10-21, 5.08 x 10-19); CCR2 with monocytes (p = 2.40 x 10-10); and CCR1 with monocytes and neutrophil (p = 1.78 x 10-6, 7.17 x 10-5). Additionally, we found that almost all examined white blood cell traits are significantly different across age and sex groups. CONCLUSIONS: Our findings suggest that altered blood cell traits, especially those of monocyte, eosinophil, and neutrophil, may represent the mechanistic links between the genetic locus 3p21.31 and severe COVID-19. They may also underlie the increased risk of severe COVID-19 in older adults and men. Twit Text FOAVip Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19 ????J Gerontol A Biol Sci Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=33530099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33530099 #FOAvip English Wikipedia <ref>{{Cite pmid|33530099}}</ref> Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19 #MMPMID33530099 Zhou J; Sun Y; Huang W; Ye K J Gerontol A Biol Sci Med Sci 2021[Jul]; 76 (8): e147-e154 PMID33530099show ga BACKGROUND: The genetic locus 3p21.31 has been associated with severe coronavirus disease 2019 (COVID-19), but the underlying pathophysiological mechanism is unknown. METHODS: To identify intermediate traits associated with the 3p21.31 locus, we first performed a phenome-wide association study (PheWAS) with 923 phenotypes in 310 999 European individuals from the UK Biobank. For genes potentially regulated by the COVID-19 risk variant, we examined associations between their expression and the polygenic score (PGS) of 1263 complex traits in a meta-analysis of 31 684 blood samples. For the prioritized blood cell traits, we tested their associations with age and sex in the same UK Biobank sample. RESULTS: Our PheWAS highlighted multiple blood cell traits to be associated with the COVID-19 risk variant, including monocyte count and percentage (p = 1.07 x 10-8, 4.09 x 10-13), eosinophil count and percentage (p = 5.73 x 10-3, 2.20 x 10-3), and neutrophil percentage (p = 3.23 x 10-3). The PGS analysis revealed positive associations between the expression of candidate genes and genetically predicted counts of specific blood cells: CCR3 with eosinophil and basophil (p = 5.73 x 10-21, 5.08 x 10-19); CCR2 with monocytes (p = 2.40 x 10-10); and CCR1 with monocytes and neutrophil (p = 1.78 x 10-6, 7.17 x 10-5). Additionally, we found that almost all examined white blood cell traits are significantly different across age and sex groups. CONCLUSIONS: Our findings suggest that altered blood cell traits, especially those of monocyte, eosinophil, and neutrophil, may represent the mechanistic links between the genetic locus 3p21.31 and severe COVID-19. They may also underlie the increased risk of severe COVID-19 in older adults and men. |*COVID-19/complications/genetics[MESH] |*Genetic Loci[MESH] |*Genome-Wide Association Study[MESH] |*Phenotype[MESH] |*Severity of Illness Index[MESH] |Aged[MESH] |Female[MESH] |Granulocytes/pathology[MESH] |Humans[MESH] |Leukocyte Count[MESH] |Male[MESH]Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COV(epmc).pdf DeepDyve Pubget Overpricing