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10.1002/cpt.2185

http://scihub22266oqcxt.onion/10.1002/cpt.2185
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33529354!8014840!33529354
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suck abstract from ncbi


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pmid33529354      Clin+Pharmacol+Ther 2021 ; 109 (4): 816-828
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  • Real-World Evidence for Assessing Pharmaceutical Treatments in the Context of COVID-19 #MMPMID33529354
  • Franklin JM; Lin KJ; Gatto NM; Rassen JA; Glynn RJ; Schneeweiss S
  • Clin Pharmacol Ther 2021[Apr]; 109 (4): 816-828 PMID33529354show ga
  • The emergence and global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an urgent need for evidence on medical interventions and outcomes of the resulting disease, coronavirus disease 2019 (COVID-19). Although many randomized controlled trials (RCTs) evaluating treatments and vaccines for COVID-19 are already in progress, the number of clinical questions of interest greatly outpaces the available resources to conduct RCTs. Therefore, there is growing interest in whether nonrandomized real-world evidence (RWE) can be used to supplement RCT evidence and aid in clinical decision making, but concerns about nonrandomized RWE have been highlighted by a proliferation of RWE studies on medications and COVID-19 outcomes with widely varying conclusions. The objective of this paper is to review some clinical questions of interest, potential data types, challenges, and merits of RWE in COVID-19, resulting in recommendations for nonrandomized RWE designs and analyses based on established RWE principles.
  • |*COVID-19 Drug Treatment[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH]
  • |COVID-19 Vaccines/administration & dosage[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Evidence-Based Medicine[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Insurance Claim Review/statistics & numerical data[MESH]
  • |Macrolides/therapeutic use[MESH]
  • |Research Design/*standards[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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