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10.1111/dom.14324

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33528920!8013481!33528920
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suck abstract from ncbi


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pmid33528920      Diabetes+Obes+Metab 2021 ; 23 (5): 1162-1172
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  • Use of dipeptidyl peptidase-4 inhibitors and prognosis of COVID-19 in hospitalized patients with type 2 diabetes: A propensity score analysis from the CORONADO study #MMPMID33528920
  • Roussel R; Darmon P; Pichelin M; Goronflot T; Abouleka Y; Ait Bachir L; Allix I; Ancelle D; Barraud S; Bordier L; Carlier A; Chevalier N; Coffin-Boutreux C; Cosson E; Dorange A; Dupuy O; Fontaine P; Fremy B; Galtier F; Germain N; Guedj AM; Larger E; Laugier-Robiolle S; Laviolle B; Ludwig L; Monier A; Montanier N; Moulin P; Moura I; Prevost G; Reznik Y; Sabbah N; Saulnier PJ; Serusclat P; Vatier C; Wargny M; Hadjadj S; Gourdy P; Cariou B
  • Diabetes Obes Metab 2021[May]; 23 (5): 1162-1172 PMID33528920show ga
  • AIM: To investigate the association between routine use of dipeptidyl peptidase-4 (DPP-4) inhibitors and the severity of coronavirus disease 2019 (COVID-19) infection in patient with type 2 diabetes in a large multicentric study. MATERIALS AND METHODS: This study was a secondary analysis of the CORONADO study on 2449 patients with type 2 diabetes (T2D) hospitalized for COVID-19 in 68 French centres. The composite primary endpoint combined tracheal intubation for mechanical ventilation and death within 7 days of admission. Stabilized weights were computed for patients based on propensity score (DPP-4 inhibitors users vs. non-users) and were used in multivariable logistic regression models to estimate the average treatment effect in the treated as inverse probability of treatment weighting (IPTW). RESULTS: Five hundred and ninety-six participants were under DPP-4 inhibitors before admission to hospital (24.3%). The primary outcome occurred at similar rates in users and non-users of DPP-4 inhibitors (27.7% vs. 28.6%; p = .68). In propensity analysis, the IPTW-adjusted models showed no significant association between the use of DPP-4 inhibitors and the primary outcome by Day 7 (OR [95% CI]: 0.95 [0.77-1.17]) or Day 28 (OR [95% CI]: 0.96 [0.78-1.17]). Similar neutral findings were found between use of DPP-4 inhibitors and the risk of tracheal intubation and death. CONCLUSIONS: These data support the safety of DPP-4 inhibitors for diabetes management during the COVID-19 pandemic and they should not be discontinued.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/complications[MESH]
  • |*Diabetes Mellitus, Type 2/complications/drug therapy/epidemiology[MESH]
  • |*Dipeptidyl-Peptidase IV Inhibitors/adverse effects/therapeutic use[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Angiotensin Receptor Antagonists[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Prognosis[MESH]


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