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10.1093/gerona/glab026 http://scihub22266oqcxt.onion/10.1093/gerona/glab026 33528568!7929343!33528568     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gerontol+A+Biol+Sci+Med+Sci 2021 ; 76 (8): e97-e101 Nephropedia Template TP {{tp|p=33528568|t=2021. The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hospitalized With COVID-19 |pdf=|usr=}}{{33528568}} gab.com Text The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hospitalized With COVID-19 JO: J Gerontol A Biol Sci Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=33528568 #FOAvip Profound T-cell lymphopenia is the hallmark of severe coronavirus disease 2019 (COVID-19). T-cell proliferation is telomere length (TL) dependent and telomeres shorten with age. Older COVID-19 patients, we hypothesize, are, therefore, at a higher risk of having TL-dependent lymphopenia. We measured TL by the novel Telomere Shortest Length Assay (TeSLA), and by Southern blotting (SB) of the terminal restriction fragments in peripheral blood mononuclear cells of 17 COVID-19 and 21 non-COVID-19 patients, aged 87 +/- 8 (mean +/- SD) and 87 +/- 9 years, respectively. TeSLA tallies and measures single telomeres, including short telomeres undetected by SB. Such telomeres are relevant to TL-mediated biological processes, including cell viability and senescence. TeSLA yields 2 key metrics: the proportions of telomeres with different lengths (expressed in %) and their mean (TeSLA mTL), (expressed in kb). Lymphocyte count (109/L) was 0.91 +/- 0.42 in COVID-19 patients and 1.50 +/- 0.50 in non-COVID-19 patients (p < .001). In COVID-19 patients, but not in non-COVID-19 patients, lymphocyte count was inversely correlated with the proportion of telomeres shorter than 2 kb (p = .005) and positively correlated with TeSLA mTL (p = .03). Lymphocyte count was not significantly correlated with SB mTL in either COVID-19 or non-COVID-19 patients. We propose that compromised TL-dependent T-cell proliferative response, driven by short telomere in the TL distribution, contributes to COVID-19 lymphopenia among old adults. We infer that infection with SARS-CoV-2 uncovers the limits of the TL reserves of older persons. Clinical Trials Registration Number: NCT04325646. Twit Text FOAVip The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hospitalized With COVID-19 ????J Gerontol A Biol Sci Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=33528568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33528568 #FOAvip English Wikipedia <ref>{{Cite pmid|33528568}}</ref> The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hospitalized With COVID-19 #MMPMID33528568 Benetos A; Lai TP; Toupance S; Labat C; Verhulst S; Gautier S; Ungeheuer MN; Perret-Guillaume C; Levy D; Susser E; Aviv A J Gerontol A Biol Sci Med Sci 2021[Jul]; 76 (8): e97-e101 PMID33528568show ga Profound T-cell lymphopenia is the hallmark of severe coronavirus disease 2019 (COVID-19). T-cell proliferation is telomere length (TL) dependent and telomeres shorten with age. Older COVID-19 patients, we hypothesize, are, therefore, at a higher risk of having TL-dependent lymphopenia. We measured TL by the novel Telomere Shortest Length Assay (TeSLA), and by Southern blotting (SB) of the terminal restriction fragments in peripheral blood mononuclear cells of 17 COVID-19 and 21 non-COVID-19 patients, aged 87 +/- 8 (mean +/- SD) and 87 +/- 9 years, respectively. TeSLA tallies and measures single telomeres, including short telomeres undetected by SB. Such telomeres are relevant to TL-mediated biological processes, including cell viability and senescence. TeSLA yields 2 key metrics: the proportions of telomeres with different lengths (expressed in %) and their mean (TeSLA mTL), (expressed in kb). Lymphocyte count (109/L) was 0.91 +/- 0.42 in COVID-19 patients and 1.50 +/- 0.50 in non-COVID-19 patients (p < .001). In COVID-19 patients, but not in non-COVID-19 patients, lymphocyte count was inversely correlated with the proportion of telomeres shorter than 2 kb (p = .005) and positively correlated with TeSLA mTL (p = .03). Lymphocyte count was not significantly correlated with SB mTL in either COVID-19 or non-COVID-19 patients. We propose that compromised TL-dependent T-cell proliferative response, driven by short telomere in the TL distribution, contributes to COVID-19 lymphopenia among old adults. We infer that infection with SARS-CoV-2 uncovers the limits of the TL reserves of older persons. Clinical Trials Registration Number: NCT04325646. |*Hospitalization[MESH] |*Lymphocyte Count[MESH] |*Lymphopenia/etiology/pathology[MESH] |Aged, 80 and over[MESH] |COVID-19/*physiopathology[MESH] |Cellular Senescence[MESH] |Humans[MESH] |SARS-CoV-2/pathogenicity[MESH] |T-Lymphocytes/immunology[MESH]The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hosp(epmc).pdf DeepDyve Pubget Overpricing