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10.1007/s00005-020-00602-5

http://scihub22266oqcxt.onion/10.1007/s00005-020-00602-5
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suck abstract from ncbi


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pmid33527308      Arch+Immunol+Ther+Exp+(Warsz) 2021 ; 69 (1): 1
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  • DPP4 Inhibitors and COVID-19-Holy Grail or Another Dead End? #MMPMID33527308
  • Krejner-Bienias A; Grzela K; Grzela T
  • Arch Immunol Ther Exp (Warsz) 2021[Feb]; 69 (1): 1 PMID33527308show ga
  • A novel coronavirus disease, COVID-19, has emerged as a global public health issue. Clinical course of disease significantly correlates with the occurrence of some comorbidities, among them type 2 diabetes. According to recent structural studies the dipeptidyl peptidase 4, a key molecule in the pathophysiology of diabetes, may influence the course of COVID-19. Since DPP4 inhibitors, gliptins, are widely used in diabetes patients, the exact role of DPP4 modulation in SARS-CoV-2 infection, at least in that group, urgently needs to be clarified. In this short review, we discuss this issue with more detail.
  • |*COVID-19 Drug Treatment[MESH]
  • |Antiviral Agents/pharmacology/*therapeutic use[MESH]
  • |COVID-19/complications/enzymology/metabolism[MESH]
  • |Diabetes Mellitus, Type 2/*complications[MESH]
  • |Dipeptidyl Peptidase 4/*metabolism[MESH]
  • |Dipeptidyl-Peptidase IV Inhibitors/pharmacology/*therapeutic use[MESH]
  • |Humans[MESH]


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