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10.1186/s41747-020-00203-z

http://scihub22266oqcxt.onion/10.1186/s41747-020-00203-z
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33527198!7850902!33527198
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suck abstract from ncbi


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pmid33527198      Eur+Radiol+Exp 2021 ; 5 (1): 7
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  • Machine learning applied on chest x-ray can aid in the diagnosis of COVID-19: a first experience from Lombardy, Italy #MMPMID33527198
  • Castiglioni I; Ippolito D; Interlenghi M; Monti CB; Salvatore C; Schiaffino S; Polidori A; Gandola D; Messa C; Sardanelli F
  • Eur Radiol Exp 2021[Feb]; 5 (1): 7 PMID33527198show ga
  • BACKGROUND: We aimed to train and test a deep learning classifier to support the diagnosis of coronavirus disease 2019 (COVID-19) using chest x-ray (CXR) on a cohort of subjects from two hospitals in Lombardy, Italy. METHODS: We used for training and validation an ensemble of ten convolutional neural networks (CNNs) with mainly bedside CXRs of 250 COVID-19 and 250 non-COVID-19 subjects from two hospitals (Centres 1 and 2). We then tested such system on bedside CXRs of an independent group of 110 patients (74 COVID-19, 36 non-COVID-19) from one of the two hospitals. A retrospective reading was performed by two radiologists in the absence of any clinical information, with the aim to differentiate COVID-19 from non-COVID-19 patients. Real-time polymerase chain reaction served as the reference standard. RESULTS: At 10-fold cross-validation, our deep learning model classified COVID-19 and non-COVID-19 patients with 0.78 sensitivity (95% confidence interval [CI] 0.74-0.81), 0.82 specificity (95% CI 0.78-0.85), and 0.89 area under the curve (AUC) (95% CI 0.86-0.91). For the independent dataset, deep learning showed 0.80 sensitivity (95% CI 0.72-0.86) (59/74), 0.81 specificity (29/36) (95% CI 0.73-0.87), and 0.81 AUC (95% CI 0.73-0.87). Radiologists' reading obtained 0.63 sensitivity (95% CI 0.52-0.74) and 0.78 specificity (95% CI 0.61-0.90) in Centre 1 and 0.64 sensitivity (95% CI 0.52-0.74) and 0.86 specificity (95% CI 0.71-0.95) in Centre 2. CONCLUSIONS: This preliminary experience based on ten CNNs trained on a limited training dataset shows an interesting potential of deep learning for COVID-19 diagnosis. Such tool is in training with new CXRs to further increase its performance.
  • |*COVID-19[MESH]
  • |*Machine Learning[MESH]
  • |*X-Rays[MESH]
  • |Aged[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Italy[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Radiographic Image Interpretation, Computer-Assisted/*methods[MESH]
  • |Radiography, Thoracic/methods[MESH]
  • |Reproducibility of Results[MESH]
  • |Retrospective Studies[MESH]


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