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10.1016/j.bbih.2021.100212 http://scihub22266oqcxt.onion/10.1016/j.bbih.2021.100212 33527097!7840406!33527097     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33527097&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Behav+Immun+Health 2021 ; 13 (ä): 100212 Nephropedia Template TP {{tp|p=33527097|t=2021. Clozapine, neutropenia and Covid-19: should clinicians be concerned? 3 months report |pdf=|usr=}}{{33527097}} gab.com Text Clozapine, neutropenia and Covid-19: should clinicians be concerned 3 months report JO: Brain Behav Immun Health http://www.kidney.de/pget.php?&tw=1&pmid=33527097 #FOAvip BACKGROUND: Clozapine is among the most effective antipsychotics used for treatment resistant schizophrenia. Adverse reactions to clozapine include neutropenia. In March 2020, at the start of the Coronavirus -19 pandemic, clinicians raised concerns regarding continuation of antipsychotic treatment, and specifically of clozapine, in patients with coronavirus disease. We aimed here at providing a short report focusing on the association between neutropenia and clozapine in a case series of psychiatric inpatients diagnosed with COVID-19. PATIENTS & METHODS: We retrospectively inspected data of 10 patients on clozapine, admitted to Highgate Mental Health Centre, Camden & Islington NHS Foundation Trust, between March and July 2020; selection was based on their COVID-19 positive PCR test. We used a linear regression model to estimate whether there was a significant drop in the neutrophil count during SARS-CoV-2 infection.The analysis was done in R using a linear regression to the origin. RESULTS: Data were collected on 10 patients, of which 7 were males. During COVID-19 infection, neutrophils' count (ANC) was 4.13 ?x ?10(9)/l (SD ?= ?2.70) which constituted a significant drop from a baseline value of 5.2 ?x ?10(9)/l (SD ?= ?2.24). The mean relative reduction in ANC was -0.2729 (SD ?= ?0.1666). The beta value of 0.8377 obtained with the linear regression showed that ANC values during SARS-CoV-2 infection were 83.77% of the baseline ANC showing that within the two time points there was a decrease of 16.23%. The linear regression had a pvalue ?= ?8.96 ?x ?10(-8) and an adjusted R(2) of 95.94% which shows that the variability of the data is very well explained by the model. We also compared baseline ANC with ANC values approximately a month after resolution of the infection and results indicate that ANC values return to a 95% of baseline. CONCLUSIONS: Clinicians should bear in mind that a significant drop in neutrophils' count may occur in patients taking clozapine and affected from a SARS-CoV-2 infectionand that this drop is only transitory. Twit Text FOAVip Clozapine, neutropenia and Covid-19: should clinicians be concerned 3 months report ????Brain Behav Immun Health http://www.kidney.de/pget.php?&tw=1&pmid=33527097 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33527097 #FOAvip English Wikipedia <ref>{{Cite pmid|33527097}}</ref> Clozapine, neutropenia and Covid-19: should clinicians be concerned? 3 months report #MMPMID33527097 Bonaccorso S; Ricciardi A; Ouabbou S; Theleritis C; Ross-Michaelides A; Metastasio A; Stewart N; Mohammed M; Schifano F Brain Behav Immun Health 2021[May]; 13 (ä): 100212 PMID33527097show ga BACKGROUND: Clozapine is among the most effective antipsychotics used for treatment resistant schizophrenia. Adverse reactions to clozapine include neutropenia. In March 2020, at the start of the Coronavirus -19 pandemic, clinicians raised concerns regarding continuation of antipsychotic treatment, and specifically of clozapine, in patients with coronavirus disease. We aimed here at providing a short report focusing on the association between neutropenia and clozapine in a case series of psychiatric inpatients diagnosed with COVID-19. PATIENTS & METHODS: We retrospectively inspected data of 10 patients on clozapine, admitted to Highgate Mental Health Centre, Camden & Islington NHS Foundation Trust, between March and July 2020; selection was based on their COVID-19 positive PCR test. We used a linear regression model to estimate whether there was a significant drop in the neutrophil count during SARS-CoV-2 infection.The analysis was done in R using a linear regression to the origin. RESULTS: Data were collected on 10 patients, of which 7 were males. During COVID-19 infection, neutrophils' count (ANC) was 4.13 ?x ?10(9)/l (SD ?= ?2.70) which constituted a significant drop from a baseline value of 5.2 ?x ?10(9)/l (SD ?= ?2.24). The mean relative reduction in ANC was -0.2729 (SD ?= ?0.1666). The beta value of 0.8377 obtained with the linear regression showed that ANC values during SARS-CoV-2 infection were 83.77% of the baseline ANC showing that within the two time points there was a decrease of 16.23%. The linear regression had a pvalue ?= ?8.96 ?x ?10(-8) and an adjusted R(2) of 95.94% which shows that the variability of the data is very well explained by the model. We also compared baseline ANC with ANC values approximately a month after resolution of the infection and results indicate that ANC values return to a 95% of baseline. CONCLUSIONS: Clinicians should bear in mind that a significant drop in neutrophils' count may occur in patients taking clozapine and affected from a SARS-CoV-2 infectionand that this drop is only transitory. äClozapine, neutropenia and Covid-19: should clinicians be concerned? 3(epmc).pdf DeepDyve Pubget Overpricing