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10.1186/s43088-021-00095-x http://scihub22266oqcxt.onion/10.1186/s43088-021-00095-x 33527080!7841026!33527080     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Beni+Suef+Univ+J+Basic+Appl+Sci 2021 ; 10 (1): 9 Nephropedia Template TP {{tp|p=33527080|t=2021. Virtual screening of phytochemical compounds as potential inhibitors against SARS-CoV-2 infection |pdf=|usr=}}{{33527080}} gab.com Text Virtual screening of phytochemical compounds as potential inhibitors against SARS-CoV-2 infection JO: Beni Suef Univ J Basic Appl Sci http://www.kidney.de/pget.php?&tw=1&pmid=33527080 #FOAvip BACKGROUND: The present pandemic situation due to coronavirus has led to the search for newer prevention, diagnostic, and treatment methods. The onset of the corona infection in a human results in acute respiratory illness followed by death if not diagnosed and treated with suitable antiretroviral drugs. With the unavailability of the targeted drug treatment, several repurposed drugs are being used for treatment. However, the side-effects of the drugs urges us to move to a search for newer synthetic- or phytochemical-based drugs. The present study investigates the use of various phytochemicals virtually screened from various plant sources in Western Ghats, India, and subsequently molecular docking studies were performed to identify the efficacy of the drug in retroviral infection particularly coronavirus infection. RESULTS: Out of 57 phytochemicals screened initially based on the structural and physicochemical properties, 39 were effectively used for the docking analysis. Finally, 5 lead compounds with highest hydrophobic interaction and number of H-bonds were screened. Results from the interaction analysis suggest Piperolactam A to be pocketed well with good hydrophobic interaction with the residues in the binding region R1. ADME and toxicity profiling also reveals Piperolactam A with higher LogS values indicating higher permeation and hydrophilicity. Toxicity profiling suggests that the 5 screened compounds to be relatively safe. CONCLUSION: The in silico methods used in this study suggests that the compound Piperolactam A to be the most effective inhibitor of S-protein from binding to the GRP78 receptor. By blocking the binding of the S-protein to the CS-GRP78 cell surface receptor, they can inhibit the binding of the virus to the host. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s43088-021-00095-x. Twit Text FOAVip Virtual screening of phytochemical compounds as potential inhibitors against SARS-CoV-2 infection ????Beni Suef Univ J Basic Appl Sci http://www.kidney.de/pget.php?&tw=1&pmid=33527080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33527080 #FOAvip English Wikipedia <ref>{{Cite pmid|33527080}}</ref> Virtual screening of phytochemical compounds as potential inhibitors against SARS-CoV-2 infection #MMPMID33527080 Kothandan R; Rajan CASG; Arjun J; Raj RRM; Syed S Beni Suef Univ J Basic Appl Sci 2021[]; 10 (1): 9 PMID33527080show ga BACKGROUND: The present pandemic situation due to coronavirus has led to the search for newer prevention, diagnostic, and treatment methods. The onset of the corona infection in a human results in acute respiratory illness followed by death if not diagnosed and treated with suitable antiretroviral drugs. With the unavailability of the targeted drug treatment, several repurposed drugs are being used for treatment. However, the side-effects of the drugs urges us to move to a search for newer synthetic- or phytochemical-based drugs. The present study investigates the use of various phytochemicals virtually screened from various plant sources in Western Ghats, India, and subsequently molecular docking studies were performed to identify the efficacy of the drug in retroviral infection particularly coronavirus infection. RESULTS: Out of 57 phytochemicals screened initially based on the structural and physicochemical properties, 39 were effectively used for the docking analysis. Finally, 5 lead compounds with highest hydrophobic interaction and number of H-bonds were screened. Results from the interaction analysis suggest Piperolactam A to be pocketed well with good hydrophobic interaction with the residues in the binding region R1. ADME and toxicity profiling also reveals Piperolactam A with higher LogS values indicating higher permeation and hydrophilicity. Toxicity profiling suggests that the 5 screened compounds to be relatively safe. CONCLUSION: The in silico methods used in this study suggests that the compound Piperolactam A to be the most effective inhibitor of S-protein from binding to the GRP78 receptor. By blocking the binding of the S-protein to the CS-GRP78 cell surface receptor, they can inhibit the binding of the virus to the host. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s43088-021-00095-x. äVirtual screening of phytochemical compounds as potential inhibitors a(epmc).pdf DeepDyve Pubget Overpricing