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10.1038/s41541-021-00283-x

http://scihub22266oqcxt.onion/10.1038/s41541-021-00283-x
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33526776!7851141!33526776
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suck abstract from ncbi


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pmid33526776      NPJ+Vaccines 2021 ; 6 (1): 22
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  • Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus #MMPMID33526776
  • Yu J; Sreenivasan C; Uprety T; Gao R; Huang C; Lee EJ; Lawson S; Nelson J; Christopher-Hennings J; Kaushik RS; Nelson E; Diel DG; Hause BM; Li F; Wang D
  • NPJ Vaccines 2021[Feb]; 6 (1): 22 PMID33526776show ga
  • Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.
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