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10.1016/j.berh.2021.101659

http://scihub22266oqcxt.onion/10.1016/j.berh.2021.101659
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33526326!7833968!33526326
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suck abstract from ncbi


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pmid33526326      Best+Pract+Res+Clin+Rheumatol 2021 ; 35 (1): 101659
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  • The protective effect of rheumatic disease agents in COVID-19 #MMPMID33526326
  • Valenzuela-Almada MO; Putman MS; Duarte-Garcia A
  • Best Pract Res Clin Rheumatol 2021[Mar]; 35 (1): 101659 PMID33526326show ga
  • Several immunosuppressive therapies have been investigated as potential treatments for patients with severe and critical coronavirus disease 2019 (COVID-19). Notable examples include corticosteroids, interleukin 6 (IL-6), interleukin 1 (IL-1), Janus kinase (JAK), and tumor necrosis factor alpha (TNF-alpha) inhibitors. The aim of this narrative review is to analyze the mechanistic rationale and available evidence for these selected anti-rheumatic drugs for the treatment of COVID-19. Currently, only corticosteroids have consistently proven to be effective in decreasing mortality and are recommended in clinical guidelines for the treatment of severe and critical COVID-19. Multiple randomized controlled trials (RCTs) are ongoing to determine the role of other immunosuppressants.
  • |*Antirheumatic Agents/therapeutic use[MESH]
  • |*COVID-19[MESH]
  • |*Rheumatic Diseases/drug therapy[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/therapeutic use[MESH]


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