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10.23750/abm.v91i4.10877

http://scihub22266oqcxt.onion/10.23750/abm.v91i4.10877
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33525212!7927527!33525212
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suck abstract from ncbi


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pmid33525212      Acta+Biomed 2020 ; 91 (4): e2020102
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  • Efficacy and safety of sofosbuvir/ ledipasvir in treatment of patients with COVID-19; A randomized clinical trial #MMPMID33525212
  • Khalili H; Nourian A; Ahmadinejad Z; Emadi Kouchak H; Jafari S; Dehghan Manshadi SA; Rasolinejad M; Kebriaeezadeh A
  • Acta Biomed 2020[Nov]; 91 (4): e2020102 PMID33525212show ga
  • BACKGROUND: There is no study regarding the use of SOF/LDP in treatment of COVID-19. Objectives: In this study, the efficacy and safety of SOF/LDP were assessed in treatment of patients with mild to moderate COVID-19. METHODS: Among an open-label randomized clinical trial, 82 patients with mild to moderated COVID-19 were assigned to receive either SOF/LDP 400/100 mg daily plus the standard of care (SOF/LDP group, n=42) or the standard of care alone (control group, n=40) for 10 days. Time to clinical response, rate of clinical response, duration of hospital and ICU stay and 14-day mortality were assessed. RESULTS: Clinical response occurred in 91.46% of patients. Although rates of clinical response were comparable between the groups but it occurred faster in the SOF/LDP group than the control group (2 vs. 4 days respectively, P= 0.02). Supportive cares were provided in the medical wards for most patients but 17.07% of patients were transferred to ICU during the hospitalization course. However, durations of hospital and ICU stay were comparable between the groups. 14--day mortality rate was 7.14% and 7.5% in the SOF/ LDP and control groups respectively. No adverse effects leading to drug discontinuation occurred. Gastrointestinal events (nausea, vomiting and diarrhea) were the most common side effects (15.85%). CONCLUSION: Added to the standard of care, SOF/LDP accelerated time to the clinical response. However, rate of clinical response, duration of hospital and ICU stay and 14-day mortality were not different. No significant adverse event was detected. More randomized clinical trials with larger sample sizes are needed to confirm the efficacy and safety of SOF/LDP in the treatment of COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aged[MESH]
  • |Antiviral Agents/adverse effects/*therapeutic use[MESH]
  • |Benzimidazoles/adverse effects/*therapeutic use[MESH]
  • |Drug Combinations[MESH]
  • |Fluorenes/adverse effects/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Severity of Illness Index[MESH]
  • |Sofosbuvir/adverse effects/*therapeutic use[MESH]


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