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10.23750/abm.v91i4.10911 http://scihub22266oqcxt.onion/10.23750/abm.v91i4.10911 33525202!7927496!33525202     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33525202.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Acta+Biomed 2020 ; 91 (4): e2020144 Nephropedia Template TP {{tp|p=33525202|t=2020. SARS-CoV-2/COVID-19 Testing: The Tower of Babel |pdf=|usr=}}{{33525202}} gab.com Text SARS-CoV-2/COVID-19 Testing: The Tower of Babel JO: Acta Biomed http://www.kidney.de/pget.php?&tw=1&pmid=33525202 #FOAvip BACKGROUND AND AIM: Testing represents one of the main pillars of public health response to SARS-CoV-2/COVID-19 pandemic. This paper shows how accuracy and utility of testing programs depend not just on the type of tests, but on the context as well. METHODS: We describe the testing methods that have been developed and the possible testing strategies; then, we focus on two possible methods of population-wide testing, i.e., pooled testing and testing with rapid antigen tests. We show the accuracy of split-pooling method and how, in different pre-test probability scenarios, the positive and negative predictive values vary using rapid antigen tests. RESULTS: Split-pooling, followed by retesting of negative results, shows a higher sensitivity than individual testing and requires fewer tests. In case of low pre-test probability, a negative result with antigen test could allow to rule out the infection, while, in case of a positive result, a confirmatory molecular test would be necessary. CONCLUSIONS: Test performance alone is not enough to properly choose which test to use; goals and context of the testing program are essential. We advocate the use of pooled strategies when planning population-wide screening, and the weekly use of rapid tests for close periodic monitoring in low-prevalence populations. Twit Text FOAVip SARS-CoV-2/COVID-19 Testing: The Tower of Babel ????Acta Biomed http://www.kidney.de/pget.php?&tw=1&pmid=33525202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33525202 #FOAvip English Wikipedia <ref>{{Cite pmid|33525202}}</ref> SARS-CoV-2/COVID-19 Testing: The Tower of Babel #MMPMID33525202 Reno C; Lenzi J; Golinelli D; Gori D; Signorelli C; Kraemer J; Stoto MA; Avitabile E; Landini MP; Lazzarotto T; Re MC; Rucci P; Taliani G; Trere D; Vocale C; Fantini MP Acta Biomed 2020[Nov]; 91 (4): e2020144 PMID33525202show ga BACKGROUND AND AIM: Testing represents one of the main pillars of public health response to SARS-CoV-2/COVID-19 pandemic. This paper shows how accuracy and utility of testing programs depend not just on the type of tests, but on the context as well. METHODS: We describe the testing methods that have been developed and the possible testing strategies; then, we focus on two possible methods of population-wide testing, i.e., pooled testing and testing with rapid antigen tests. We show the accuracy of split-pooling method and how, in different pre-test probability scenarios, the positive and negative predictive values vary using rapid antigen tests. RESULTS: Split-pooling, followed by retesting of negative results, shows a higher sensitivity than individual testing and requires fewer tests. In case of low pre-test probability, a negative result with antigen test could allow to rule out the infection, while, in case of a positive result, a confirmatory molecular test would be necessary. CONCLUSIONS: Test performance alone is not enough to properly choose which test to use; goals and context of the testing program are essential. We advocate the use of pooled strategies when planning population-wide screening, and the weekly use of rapid tests for close periodic monitoring in low-prevalence populations. |*COVID-19 Testing[MESH] |COVID-19/*diagnosis[MESH] |Humans[MESH] |Predictive Value of Tests[MESH] |ROC Curve[MESH]SARS-CoV-2/COVID-19 Testing: The Tower of Babel (epmc).pdf DeepDyve Pubget Overpricing