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10.1159/000514225 http://scihub22266oqcxt.onion/10.1159/000514225 33524979!7900461!33524979     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Arch+Allergy+Immunol 2021 ; 182 (4): 339-349 Nephropedia Template TP {{tp|p=33524979|t=2021. Principles and Challenges in anti-COVID-19 Vaccine Development |pdf=|usr=}}{{33524979}} gab.com Text Principles and Challenges in anti-COVID-19 Vaccine Development JO: Int Arch Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33524979 #FOAvip The number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients keeps rising in most of the European countries despite the pandemic precaution measures. The current antiviral and anti-inflammatory therapeutic approaches are only supportive, have limited efficacy, and the prevention in reducing the transmission of SARS-CoV-2 virus is the best hope for public health. It is presumed that an effective vaccination against SARS-CoV-2 infection could mobilize the innate and adaptive immune responses and provide a protection against severe forms of coronavirus disease 2019 (COVID-19) disease. As the race for the effective and safe vaccine has begun, different strategies were introduced. To date, viral vector-based vaccines, genetic vaccines, attenuated vaccines, and protein-based vaccines are the major vaccine types tested in the clinical trials. Over 80 clinical trials have been initiated; however, only 18 vaccines have reached the clinical phase II/III or III, and 4 vaccine candidates are under consideration or have been approved for the use so far. In addition, the protective effect of the off-target vaccines, such as Bacillus Calmette-Guerin and measles vaccine, is being explored in randomized prospective clinical trials with SARS-CoV-2-infected patients. In this review, we discuss the most promising anti-COVID-19 vaccine clinical trials and different vaccination strategies in order to provide more clarity into the ongoing clinical trials. Twit Text FOAVip Principles and Challenges in anti-COVID-19 Vaccine Development ????Int Arch Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33524979 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33524979 #FOAvip English Wikipedia <ref>{{Cite pmid|33524979}}</ref> Principles and Challenges in anti-COVID-19 Vaccine Development #MMPMID33524979 Strizova Z; Smetanova J; Bartunkova J; Milota T Int Arch Allergy Immunol 2021[]; 182 (4): 339-349 PMID33524979show ga The number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients keeps rising in most of the European countries despite the pandemic precaution measures. The current antiviral and anti-inflammatory therapeutic approaches are only supportive, have limited efficacy, and the prevention in reducing the transmission of SARS-CoV-2 virus is the best hope for public health. It is presumed that an effective vaccination against SARS-CoV-2 infection could mobilize the innate and adaptive immune responses and provide a protection against severe forms of coronavirus disease 2019 (COVID-19) disease. As the race for the effective and safe vaccine has begun, different strategies were introduced. To date, viral vector-based vaccines, genetic vaccines, attenuated vaccines, and protein-based vaccines are the major vaccine types tested in the clinical trials. Over 80 clinical trials have been initiated; however, only 18 vaccines have reached the clinical phase II/III or III, and 4 vaccine candidates are under consideration or have been approved for the use so far. In addition, the protective effect of the off-target vaccines, such as Bacillus Calmette-Guerin and measles vaccine, is being explored in randomized prospective clinical trials with SARS-CoV-2-infected patients. In this review, we discuss the most promising anti-COVID-19 vaccine clinical trials and different vaccination strategies in order to provide more clarity into the ongoing clinical trials. |*COVID-19 Vaccines/administration & dosage/immunology[MESH] |*Research Design[MESH] |COVID-19/immunology/*prevention & control/virology[MESH] |Clinical Trials as Topic/*methods[MESH] |Humans[MESH]Principles and Challenges in anti-COVID-19 Vaccine Development (epmc).pdf DeepDyve Pubget Overpricing