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10.1016/j.hrtlng.2021.01.011

http://scihub22266oqcxt.onion/10.1016/j.hrtlng.2021.01.011
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33524866!7816593!33524866
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suck abstract from ncbi


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pmid33524866      Heart+Lung 2021 ; 50 (2): 357-360
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  • COVID-19 Coagulopathy: Current knowledge and guidelines on anticoagulation #MMPMID33524866
  • Salabei JK; Fishman TJ; Asnake ZT; Ali A; Iyer UG
  • Heart Lung 2021[Mar]; 50 (2): 357-360 PMID33524866show ga
  • COVID-19-associated coagulopathy (CAC) is a feature of COVID-19 that can lead to various thrombotic complications and death. In this review, we briefly highlight possible etiologies, including direct cytotoxicity caused by the SARS-CoV-2 virus, and the activation of proinflammatory molecules such as cytokines, underlying coagulopathy. Endothelial dysfunction has been highlighted as pivotal, irrespective of the mechanism involved in CAC. Specific features of CAC distinguishing it from disseminated intravascular coagulopathy and sepsis or ARDS-associated coagulopathy have been discussed. We have also highlighted some hematological parameters, such as elevated d-dimers and partial prothrombin and prothrombin times prolongation, which can guide the use of anticoagulation in critically ill patients. We conclude by highlighting the importance of prophylactic anticoagulation in all COVID-19 hospitalized patients and reiterate the need for institution-specific guidelines for anticoagulation COVID-19 patients since individual institutions have different patient populations.
  • |*Blood Coagulation Disorders/drug therapy/etiology[MESH]
  • |*COVID-19[MESH]
  • |Anticoagulants/adverse effects[MESH]
  • |Fibrin Fibrinogen Degradation Products[MESH]
  • |Humans[MESH]


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