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10.1093/infdis/jiab065 http://scihub22266oqcxt.onion/10.1093/infdis/jiab065 33524124!7928798!33524124     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33524124.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Infect+Dis 2021 ; 223 (8): 1322-1333 Nephropedia Template TP {{tp|p=33524124|t=2021. Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19 |pdf=|usr=}}{{33524124}} gab.com Text Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19 JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33524124 #FOAvip The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive proinflammatory immune response and profound lymphopenia. Inflammatory responses according to disease severity were explored by plasma cytokine measurements and proteomics analysis in 147 COVID-19 patients. Furthermore, peripheral blood mononuclear cell cytokine production assays and whole blood flow cytometry were performed. Results confirm a hyperinflammatory innate immune state, while highlighting hepatocyte growth factor and stem cell factor as potential biomarkers for disease severity. Clustering analysis revealed no specific inflammatory endotypes in COVID-19 patients. Functional assays revealed abrogated adaptive cytokine production (interferon-gamma, interleukin-17, and interleukin-22) and prominent T-cell exhaustion in critically ill patients, whereas innate immune responses were intact or hyperresponsive. Collectively, this extensive analysis provides a comprehensive insight into the pathobiology of severe to critical COVID-19 and highlights potential biomarkers of disease severity. Twit Text FOAVip Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19 ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33524124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33524124 #FOAvip English Wikipedia <ref>{{Cite pmid|33524124}}</ref> Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19 #MMPMID33524124 Janssen NAF; Grondman I; de Nooijer AH; Boahen CK; Koeken VACM; Matzaraki V; Kumar V; He X; Kox M; Koenen HJPM; Smeets RL; Joosten I; Bruggemann RJM; Kouijzer IJE; van der Hoeven HG; Schouten JA; Frenzel T; Reijers MHE; Hoefsloot W; Dofferhoff ASM; van Apeldoorn MJ; Blaauw MJT; Veerman K; Maas C; Schoneveld AH; Hoefer IE; Derde LPG; van Deuren M; van der Meer JWM; van Crevel R; Giamarellos-Bourboulis EJ; Joosten LAB; van den Heuvel MM; Hoogerwerf J; de Mast Q; Pickkers P; Netea MG; van de Veerdonk FL J Infect Dis 2021[Apr]; 223 (8): 1322-1333 PMID33524124show ga The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive proinflammatory immune response and profound lymphopenia. Inflammatory responses according to disease severity were explored by plasma cytokine measurements and proteomics analysis in 147 COVID-19 patients. Furthermore, peripheral blood mononuclear cell cytokine production assays and whole blood flow cytometry were performed. Results confirm a hyperinflammatory innate immune state, while highlighting hepatocyte growth factor and stem cell factor as potential biomarkers for disease severity. Clustering analysis revealed no specific inflammatory endotypes in COVID-19 patients. Functional assays revealed abrogated adaptive cytokine production (interferon-gamma, interleukin-17, and interleukin-22) and prominent T-cell exhaustion in critically ill patients, whereas innate immune responses were intact or hyperresponsive. Collectively, this extensive analysis provides a comprehensive insight into the pathobiology of severe to critical COVID-19 and highlights potential biomarkers of disease severity. |Adaptive Immunity/*immunology[MESH] |Aged[MESH] |Biomarkers/blood[MESH] |COVID-19/blood/*immunology/virology[MESH] |Cytokine Release Syndrome/blood/immunology/virology[MESH] |Cytokines/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Innate/*immunology[MESH] |Inflammation/blood/immunology/virology[MESH] |Leukocytes, Mononuclear/immunology/virology[MESH] |Lymphopenia/blood/immunology/virology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/immunology[MESH]Dysregulated Innate and Adaptive Immune Responses Discriminate Disease(epmc).pdf DeepDyve Pubget Overpricing