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10.1039/d0cs01118e

http://scihub22266oqcxt.onion/10.1039/d0cs01118e
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33524090!ä!33524090

suck abstract from ncbi


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pmid33524090      Chem+Soc+Rev 2021 ; 50 (6): 3647-3655
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  • Antiviral drug discovery: preparing for the next pandemic #MMPMID33524090
  • Adamson CS; Chibale K; Goss RJM; Jaspars M; Newman DJ; Dorrington RA
  • Chem Soc Rev 2021[Mar]; 50 (6): 3647-3655 PMID33524090show ga
  • Clinically approved antiviral drugs are currently available for only 10 of the more than 220 viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need for compounds that can be rapidly mobilised for the treatment of re-emerging or emerging viral diseases, while vaccine development is underway. We review the current status of antiviral therapies focusing on RNA viruses, highlighting strategies for antiviral drug discovery and discuss the challenges, solutions and options to accelerate drug discovery efforts.
  • |*COVID-19 Drug Treatment[MESH]
  • |Antiviral Agents/chemistry/*pharmacology[MESH]
  • |Biological Products/chemistry/pharmacology[MESH]
  • |COVID-19/prevention & control/virology[MESH]
  • |Coronavirus Protease Inhibitors/chemistry/pharmacology[MESH]
  • |Drug Discovery/*methods[MESH]
  • |Humans[MESH]
  • |Molecular Docking Simulation[MESH]
  • |Molecular Targeted Therapy/*methods[MESH]
  • |Nucleic Acid Synthesis Inhibitors/chemistry/pharmacology[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |RNA, Viral/*antagonists & inhibitors/chemistry/genetics/metabolism[MESH]
  • |SARS-CoV-2/chemistry/drug effects/enzymology/genetics[MESH]


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