Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pone.0245962 http://scihub22266oqcxt.onion/10.1371/journal.pone.0245962 33524017!7850479!33524017     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (2): e0245962 Nephropedia Template TP {{tp|p=33524017|t=2021. A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease |pdf=|usr=}}{{33524017}} gab.com Text A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33524017 #FOAvip Effective SARS-CoV-2 antiviral drugs are desperately needed. The SARS-CoV-2 main protease (Mpro) appears as an attractive target for drug development. We show that the existing pharmacopeia contains many drugs with potential for therapeutic repurposing as selective and potent inhibitors of SARS-CoV-2 Mpro. We screened a collection of ~6,070 drugs with a previous history of use in humans for compounds that inhibit the activity of Mpro in vitro and found ~50 compounds with activity against Mpro. Subsequent dose validation studies demonstrated 8 dose responsive hits with an IC50 </= 50 muM. Hits from our screen are enriched with hepatitis C NS3/4A protease targeting drugs including boceprevir, ciluprevir. narlaprevir, and telaprevir. This work suggests previous large-scale commercial drug development initiatives targeting hepatitis C NS3/4A viral protease should be revisited because some previous lead compounds may be more potent against SARS-CoV-2 Mpro than boceprevir and suitable for rapid repurposing. Twit Text FOAVip A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33524017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33524017 #FOAvip English Wikipedia <ref>{{Cite pmid|33524017}}</ref> A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease #MMPMID33524017 Baker JD; Uhrich RL; Kraemer GC; Love JE; Kraemer BC PLoS One 2021[]; 16 (2): e0245962 PMID33524017show ga Effective SARS-CoV-2 antiviral drugs are desperately needed. The SARS-CoV-2 main protease (Mpro) appears as an attractive target for drug development. We show that the existing pharmacopeia contains many drugs with potential for therapeutic repurposing as selective and potent inhibitors of SARS-CoV-2 Mpro. We screened a collection of ~6,070 drugs with a previous history of use in humans for compounds that inhibit the activity of Mpro in vitro and found ~50 compounds with activity against Mpro. Subsequent dose validation studies demonstrated 8 dose responsive hits with an IC50 |*Drug Evaluation, Preclinical[MESH] |*Drug Repositioning[MESH] |Antiviral Agents/*pharmacology/*therapeutic use[MESH] |Biological Assay[MESH] |Fluorescence[MESH] |Hepacivirus/*drug effects[MESH] |Hepatitis C/*drug therapy[MESH] |High-Throughput Screening Assays[MESH] |Humans[MESH] |Protease Inhibitors/*pharmacology[MESH] |Reproducibility of Results[MESH]A drug repurposing screen identifies hepatitis C antivirals as inhibit(epmc).pdf DeepDyve Pubget Overpricing