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10.1021/acsbiomaterials.0c01710

http://scihub22266oqcxt.onion/10.1021/acsbiomaterials.0c01710
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33523642!ä!33523642

suck abstract from ncbi


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pmid33523642      ACS+Biomater+Sci+Eng 2021 ; 7 (3): 963-982
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  • Synthesis and Biopharmaceutical Applications of Sugar-Based Polymers: New Advances and Future Prospects #MMPMID33523642
  • Wang J; Wang D; Zhang Y; Dong J
  • ACS Biomater Sci Eng 2021[Mar]; 7 (3): 963-982 PMID33523642show ga
  • The rapid rise in research interest in carbohydrate-based polymers is undoubtedly due to the nontoxic nature of such materials in an in vivo environment and the versatile roles that the polymers can play in cellular functions. Such polymers have served as therapeutic tools for drug delivery, including antigens, proteins, and genes, as well as diagnostic devices. Our focus in the first half of this Review is on synthetic methods based on ring-opening polymerization and enzyme-catalyzed polymerization, along with controlled radical polymerization. In the second half of this Review, sugar-based polymers are discussed on the basis of their remarkable success in competitive receptor binding, as multifunctional nanocarriers of targeting inhibitors for cancer treatment, in genome-editing delivery, in immunotherapy based on endogenous antibody recruitment, and in treatment of respiratory diseases, including influenza A. Particular emphasis is put on the synthesis and biopharmaceutical applications of sugar-based polymers published in the most recent 5 years. A noticeable attribute of carbohydrate-based polymers is that the sugar-receptor interactions can be facilitated by the cooperative effect of multiple sugar units. Their diversified topology and structures will drive the development of new synthetic strategies and bring about important applications, including coronavirus-related drug therapy.
  • |Animals[MESH]
  • |Antineoplastic Agents/chemical synthesis/metabolism/therapeutic use[MESH]
  • |Antiviral Agents/chemical synthesis/metabolism/therapeutic use[MESH]
  • |Cell Line, Tumor[MESH]
  • |Drug Carriers/chemical synthesis/metabolism/therapeutic use[MESH]
  • |Enzyme Inhibitors/chemical synthesis/metabolism/therapeutic use[MESH]
  • |Gene Transfer Techniques[MESH]
  • |Glycosides/*chemical synthesis/metabolism/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Influenza A virus/drug effects[MESH]
  • |Lectins/metabolism[MESH]
  • |Nanoparticles/chemistry/therapeutic use[MESH]


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