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10.1111/tid.13576

http://scihub22266oqcxt.onion/10.1111/tid.13576
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33523551!7994986!33523551
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suck abstract from ncbi


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pmid33523551      Transpl+Infect+Dis 2021 ; 23 (4): e13576
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  • Clinical course of severe COVID19 treated with tocilizumab and antivirals post-allogeneic stem cell transplant with extensive chronic GVHD #MMPMID33523551
  • Mirgh S; Gokarn A; Punatar S; Chichra A; Singh A; Rajendra A; Babu Goli V; Trivedi B; Joshi A; Patkar N; Tembhare P; Subramanian PG; Shetty N; Chavan P; Bhat V; Gupta S; Khattry N
  • Transpl Infect Dis 2021[Aug]; 23 (4): e13576 PMID33523551show ga
  • Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are an immunocompromised group who are likely to develop severe complications and mortality because of coronavirus disease 2019 (COVID-19). We report here a 61-year-old male patient of primary myelofibrosis who underwent an allo-HSCT 6 years earlier, had chronic graft-versus-host disease (cGVHD) involving the liver, lung, eyes, and skin, (with recurrent episodes of pulmonary infections) who developed severe COVID-19. The patient was treated with tocilizumab, and a combination of lopinavir/ritonavir, ribavirin, interferon-beta1b. He was discharged after 31 days with full recovery. Tocilizumab, a humanized monoclonal antibody against IL6, has been shown to benefit respiratory manifestations in severe COVID19. However, this is first report, to our knowledge, of its use and benefit in a post HSCT recipient.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Graft vs Host Disease/drug therapy[MESH]
  • |*Hematopoietic Stem Cell Transplantation/adverse effects[MESH]
  • |Antibodies, Monoclonal, Humanized[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2[MESH]


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