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10.1016/j.medj.2020.12.006

http://scihub22266oqcxt.onion/10.1016/j.medj.2020.12.006
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33521747!7833318!33521747
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suck abstract from ncbi


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pmid33521747      Med 2021 ; 2 (3): 243-262.e8
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  • A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice #MMPMID33521747
  • Silva-Cayetano A; Foster WS; Innocentin S; Belij-Rammerstorfer S; Spencer AJ; Burton OT; Fra-Bido S; Le Lee J; Thakur N; Conceicao C; Wright D; Barrett J; Evans-Bailey N; Noble C; Bailey D; Liston A; Gilbert SC; Lambe T; Linterman MA
  • Med 2021[Mar]; 2 (3): 243-262.e8 PMID33521747show ga
  • BACKGROUND: The spread of SARS-CoV-2 has caused a worldwide pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity and mortality caused by infection and may enable the relaxation of social-distancing measures. Age is one of the most significant risk factors for poor health outcomes after SARS-CoV-2 infection; therefore, it is desirable that any new vaccine candidates elicit a robust immune response in older adults. METHODS: Here, we use in-depth immunophenotyping to characterize the innate and adaptive immune response induced upon intramuscular administration of the adenoviral vectored ChAdOx1 nCoV-19 (AZD-1222) COVID-19 vaccine candidate in mice. FINDINGS: A single vaccination generates spike-specific Th1 cells, Th1-like Foxp3(+) regulatory T cells, polyfunctional spike-specific CD8(+) T cells. and granzyme-B-producing CD8 effectors. Spike-specific IgG and IgM are generated from both the early extrafollicular antibody response and the T follicular helper cell-supported germinal center reaction, which is associated with the production of virus-neutralizing antibodies. A single dose of this vaccine generated a similar type of immune response in aged mice but of a reduced magnitude than in younger mice. We report that a second dose enhances the immune response to this vaccine in aged mice. CONCLUSIONS: This study shows that ChAdOx1 nCoV-19 induces both cellular and humoral immunity in adult and aged mice and suggests a prime-boost strategy is a rational approach to enhance immunogenicity in older persons. FUNDING: This study was supported by BBSRC, Lister institute of Preventative Medicine, EPSRC VaxHub, and Innovate UK.
  • |*COVID-19 Vaccines[MESH]
  • |*COVID-19/prevention & control[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Animals[MESH]
  • |CD8-Positive T-Lymphocytes[MESH]
  • |ChAdOx1 nCoV-19[MESH]
  • |Humans[MESH]
  • |Mice[MESH]


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