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10.1016/j.xcrm.2020.100166 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100166 33521697!7817872!33521697     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33521697.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep+Med 2021 ; 2 (1): 100166 Nephropedia Template TP {{tp|p=33521697|t=2021. A distinct innate immune signature marks progression from mild to severe COVID-19 |pdf=|usr=}}{{33521697}} gab.com Text A distinct innate immune signature marks progression from mild to severe COVID-19 JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33521697 #FOAvip Coronavirus disease 2019 (COVID-19) manifests with a range of severities, but immune signatures of mild and severe disease are still not fully understood. Here, we use mass cytometry and targeted proteomics to profile the innate immune response of patients with mild or severe COVID-19 and of healthy individuals. Sampling at different stages allows us to reconstruct a pseudo-temporal trajectory of the innate response. A surge of CD169(+) monocytes associated with an IFN-gamma(+)MCP-2(+) signature rapidly follows symptom onset. At later stages, we observe a persistent inflammatory phenotype in patients with severe disease, dominated by high CCL3 and CCL4 abundance correlating with the re-appearance of CD16(+) monocytes, whereas the response of mild COVID-19 patients normalizes. Our data provide insights into the dynamic nature of inflammatory responses in COVID-19 patients and identify sustained innate immune responses as a likely mechanism in severe patients, thus supporting the investigation of targeted interventions in severe COVID-19. Twit Text FOAVip A distinct innate immune signature marks progression from mild to severe COVID-19 ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33521697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33521697 #FOAvip English Wikipedia <ref>{{Cite pmid|33521697}}</ref> A distinct innate immune signature marks progression from mild to severe COVID-19 #MMPMID33521697 Chevrier S; Zurbuchen Y; Cervia C; Adamo S; Raeber ME; de Souza N; Sivapatham S; Jacobs A; Bachli E; Rudiger A; Stussi-Helbling M; Huber LC; Schaer DJ; Nilsson J; Boyman O; Bodenmiller B Cell Rep Med 2021[Jan]; 2 (1): 100166 PMID33521697show ga Coronavirus disease 2019 (COVID-19) manifests with a range of severities, but immune signatures of mild and severe disease are still not fully understood. Here, we use mass cytometry and targeted proteomics to profile the innate immune response of patients with mild or severe COVID-19 and of healthy individuals. Sampling at different stages allows us to reconstruct a pseudo-temporal trajectory of the innate response. A surge of CD169(+) monocytes associated with an IFN-gamma(+)MCP-2(+) signature rapidly follows symptom onset. At later stages, we observe a persistent inflammatory phenotype in patients with severe disease, dominated by high CCL3 and CCL4 abundance correlating with the re-appearance of CD16(+) monocytes, whereas the response of mild COVID-19 patients normalizes. Our data provide insights into the dynamic nature of inflammatory responses in COVID-19 patients and identify sustained innate immune responses as a likely mechanism in severe patients, thus supporting the investigation of targeted interventions in severe COVID-19. |*Immunity, Innate[MESH] |Adult[MESH] |C-Reactive Protein/analysis[MESH] |COVID-19/*immunology/pathology/virology[MESH] |Cytokines/blood[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Mass Spectrometry[MESH] |Middle Aged[MESH] |Monocytes/cytology/metabolism[MESH] |Myeloid Cells/cytology/metabolism[MESH] |Proteomics/methods[MESH] |SARS-CoV-2/isolation & purification[MESH] |Severity of Illness Index[MESH]A distinct innate immune signature marks progression from mild to seve(epmc).pdf DeepDyve Pubget Overpricing