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10.1016/j.bbih.2020.100196

http://scihub22266oqcxt.onion/10.1016/j.bbih.2020.100196
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33521688!7834441!33521688
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suck abstract from ncbi


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pmid33521688      Brain+Behav+Immun+Health 2021 ; 11 (ä): 100196
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  • COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders #MMPMID33521688
  • Quincozes-Santos A; Rosa RL; Tureta EF; Bobermin LD; Berger M; Guimaraes JA; Santi L; Beys-da-Silva WO
  • Brain Behav Immun Health 2021[Feb]; 11 (ä): 100196 PMID33521688show ga
  • Coronavirus disease 2019 (COVID-19) was initially characterized due to its impacts on the respiratory system; however, many recent studies have indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly affects the brain. COVID-19 can cause neurological complications, probably caused by the induction of a cytokine storm, since there is no evidence of neurotropism by SARS-CoV-2. In line with this, the COVID-19 outbreak could accelerate the progression or affect the clinical outcomes of neuropsychiatric conditions. Thus, we analyzed differential gene expression datasets for clinical samples of COVID-19 patients and identified 171 genes that are associated with the pathophysiology of the following neuropsychiatric disorders: alcohol dependence, autism, bipolar disorder, depression, panic disorder, schizophrenia, and sleep disorder. Several of the genes identified are associated with causing some of these conditions (classified as elite genes). Among these elite genes, 9 were found for schizophrenia, 6 for autism, 3 for depression/major depressive disorder, and 2 for alcohol dependence. The patients with the neuropsychiatric conditions associated with the genes identified may require special attention as COVID-19 can deteriorate or accelerate neurochemical dysfunctions, thereby aggravating clinical outcomes.
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