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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 An+Pediatr+(Engl+Ed) 2020 ; 93 (1): 60.e1-60.e7 Nephropedia Template TP
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Narrative review of the immune response against coronavirus: An overview, applicability for SARS-COV-2, and therapeutic implications #MMPMID33521168
Garcia-Salido A
An Pediatr (Engl Ed) 2020[Jul]; 93 (1): 60.e1-60.e7 PMID33521168show ga
The new coronavirus (SARS-CoV-2) that causes a severe acute respiratory syndrome emerges in Wuhan, China, in December 2019. It produces the aforementioned disease due to coronavirus 2019 (COVID-19), and has led to a declaration of a world public health emergency by the World Health Organisation. This new SARS-CoV-2 virus could share characteristics and an immune response similar to those described for other coronavirus. Given its activity on the interferon pathway, and the manner in which it dysregulates innate immunity, the use of treatments directed at modulating or containing this could be of interest. A narrative review was made of the current evidence about immunity against coronavirus and its applicability to SARS-CoV-2. The physiopathogenesis is also described, along with the underlying leucocyte activity, with the intention of clarifying the possible usefulness of inflammatory biomarkers and the development of personalised treatments.