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10.12998/wjcc.v9.i2.296 http://scihub22266oqcxt.onion/10.12998/wjcc.v9.i2.296 33521098!7812885!33521098     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Clin+Cases 2021 ; 9 (2): 296-307 Nephropedia Template TP {{tp|p=33521098|t=2021. Effect of a fever in viral infections - the Goldilocks phenomenon?|pdf=|usr=}}{{33521098}} gab.com Text Effect of a fever in viral infections - the Goldilocks phenomenon JO: World J Clin Cases http://www.kidney.de/pget.php?&tw=1&pmid=33521098 #FOAvip Acute infections, including those due to Coronaviridae and other viruses, often stimulate a febrile response. A mild fever appears to improve outcome; it appears to diminish viral replication by several mechanisms, including virion entry into host cells and genome transcription, and improving host defence mechanisms against the pathogen. However, a fever may also damage host cellular and tissue function and increase metabolic demands. At temperatures at the lower end of the febrile range, the benefit of the fever appears to outweigh the detrimental effects. However, at higher temperatures, the outcome worsens, suggesting that the disadvantages of fever on the host predominate. A non-infective fever is associated with a worse outcome at lower temperatures, suggesting that hyperthermia carries less benefit in the absence of infection. This review discusses the risks and benefits of a fever on the host response, focusing on the effects of a fever on viral replication and host response, and the detrimental effect on the host. Twit Text FOAVip Effect of a fever in viral infections - the Goldilocks phenomenon ????World J Clin Cases http://www.kidney.de/pget.php?&tw=1&pmid=33521098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33521098 #FOAvip English Wikipedia <ref>{{Cite pmid|33521098}}</ref> Effect of a fever in viral infections - the Goldilocks phenomenon? #MMPMID33521098 Belon L; Skidmore P; Mehra R; Walter E World J Clin Cases 2021[Jan]; 9 (2): 296-307 PMID33521098show ga Acute infections, including those due to Coronaviridae and other viruses, often stimulate a febrile response. A mild fever appears to improve outcome; it appears to diminish viral replication by several mechanisms, including virion entry into host cells and genome transcription, and improving host defence mechanisms against the pathogen. However, a fever may also damage host cellular and tissue function and increase metabolic demands. At temperatures at the lower end of the febrile range, the benefit of the fever appears to outweigh the detrimental effects. However, at higher temperatures, the outcome worsens, suggesting that the disadvantages of fever on the host predominate. A non-infective fever is associated with a worse outcome at lower temperatures, suggesting that hyperthermia carries less benefit in the absence of infection. This review discusses the risks and benefits of a fever on the host response, focusing on the effects of a fever on viral replication and host response, and the detrimental effect on the host. äEffect of a fever in viral infections - the Goldilocks phenomenon?(epmc).pdf DeepDyve Pubget Overpricing