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10.3389/fimmu.2020.604944 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.604944 33519814!7840604!33519814     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 604944 Nephropedia Template TP {{tp|p=33519814|t=2020. Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury |pdf=|usr=}}{{33519814}} gab.com Text Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33519814 #FOAvip Hypoxia and inflammation often coincide in pathogenic conditions such as acute respiratory distress syndrome (ARDS) and chronic lung diseases, which are significant contributors to morbidity and mortality for the general population. For example, the recent global outbreak of Coronavirus disease 2019 (COVID-19) has placed viral infection-induced ARDS under the spotlight. Moreover, chronic lung disease ranks the third leading cause of death in the United States. Hypoxia signaling plays a diverse role in both acute and chronic lung inflammation, which could partially be explained by the divergent function of downstream target pathways such as adenosine signaling. Particularly, hypoxia signaling activates adenosine signaling to inhibit the inflammatory response in ARDS, while in chronic lung diseases, it promotes inflammation and tissue injury. In this review, we discuss the role of adenosine at the interphase of hypoxia and inflammation in ARDS and chronic lung diseases, as well as the current strategy for therapeutic targeting of the adenosine signaling pathway. Twit Text FOAVip Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33519814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33519814 #FOAvip English Wikipedia <ref>{{Cite pmid|33519814}}</ref> Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury #MMPMID33519814 Li X; Berg NK; Mills T; Zhang K; Eltzschig HK; Yuan X Front Immunol 2020[]; 11 (ä): 604944 PMID33519814show ga Hypoxia and inflammation often coincide in pathogenic conditions such as acute respiratory distress syndrome (ARDS) and chronic lung diseases, which are significant contributors to morbidity and mortality for the general population. For example, the recent global outbreak of Coronavirus disease 2019 (COVID-19) has placed viral infection-induced ARDS under the spotlight. Moreover, chronic lung disease ranks the third leading cause of death in the United States. Hypoxia signaling plays a diverse role in both acute and chronic lung inflammation, which could partially be explained by the divergent function of downstream target pathways such as adenosine signaling. Particularly, hypoxia signaling activates adenosine signaling to inhibit the inflammatory response in ARDS, while in chronic lung diseases, it promotes inflammation and tissue injury. In this review, we discuss the role of adenosine at the interphase of hypoxia and inflammation in ARDS and chronic lung diseases, as well as the current strategy for therapeutic targeting of the adenosine signaling pathway. |Acute Lung Injury/etiology/metabolism/pathology/therapy[MESH] |Adenosine/*metabolism[MESH] |Disease Management[MESH] |Disease Susceptibility[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1/metabolism[MESH] |Hypoxia/*metabolism[MESH] |Inflammation/etiology/*metabolism[MESH] |Molecular Targeted Therapy[MESH] |Receptors, Purinergic P1/metabolism[MESH] |Respiratory Distress Syndrome/etiology/metabolism/pathology/therapy[MESH]Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury(epmc).pdf DeepDyve Pubget Overpricing