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10.1016/j.ceca.2021.102360 http://scihub22266oqcxt.onion/10.1016/j.ceca.2021.102360 33516131!7825922!33516131     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Calcium 2021 ; 94 (ä): 102360 Nephropedia Template TP {{tp|p=33516131|t=2021. Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2 |pdf=|usr=}}{{33516131}} gab.com Text Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2 JO: Cell Calcium http://www.kidney.de/pget.php?&tw=1&pmid=33516131 #FOAvip Ion channels are necessary for correct lysosomal function including degradation of cargoes originating from endocytosis. Almost all enveloped viruses, including coronaviruses (CoVs), enter host cells via endocytosis, and do not escape endosomal compartments into the cytoplasm (via fusion with the endolysosomal membrane) unless the virus-encoded envelope proteins are cleaved by lysosomal proteases. With the ongoing outbreak of severe acute respiratory syndrome (SARS)-CoV-2, endolysosomal two-pore channels represent an exciting and emerging target for antiviral therapies. This review focuses on the latest knowledge of the effects of lysosomal ion channels on the cellular entry and uncoating of enveloped viruses, which may aid in development of novel therapies against emerging infectious diseases such as SARS-CoV-2. Twit Text FOAVip Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2 ????Cell Calcium http://www.kidney.de/pget.php?&tw=1&pmid=33516131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33516131 #FOAvip English Wikipedia <ref>{{Cite pmid|33516131}}</ref> Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2 #MMPMID33516131 Zhao Z; Qin P; Huang YW Cell Calcium 2021[Mar]; 94 (ä): 102360 PMID33516131show ga Ion channels are necessary for correct lysosomal function including degradation of cargoes originating from endocytosis. Almost all enveloped viruses, including coronaviruses (CoVs), enter host cells via endocytosis, and do not escape endosomal compartments into the cytoplasm (via fusion with the endolysosomal membrane) unless the virus-encoded envelope proteins are cleaved by lysosomal proteases. With the ongoing outbreak of severe acute respiratory syndrome (SARS)-CoV-2, endolysosomal two-pore channels represent an exciting and emerging target for antiviral therapies. This review focuses on the latest knowledge of the effects of lysosomal ion channels on the cellular entry and uncoating of enveloped viruses, which may aid in development of novel therapies against emerging infectious diseases such as SARS-CoV-2. |*Virus Internalization/drug effects[MESH] |*Virus Uncoating/drug effects[MESH] |Aminopyridines/pharmacology/therapeutic use[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |COVID-19/*virology[MESH] |Drug Design[MESH] |Endocytosis[MESH] |Endosomes/metabolism/virology[MESH] |Heterocyclic Compounds, 3-Ring/pharmacology/therapeutic use[MESH] |Humans[MESH] |Hydrazones/pharmacology/therapeutic use[MESH] |Ion Channels/classification/*physiology[MESH] |Lysosomes/enzymology/metabolism/*virology[MESH] |Models, Biological[MESH] |Morpholines/pharmacology/therapeutic use[MESH] |Pyrimidines/pharmacology/therapeutic use[MESH] |SARS-CoV-2/*physiology[MESH] |Vacuolar Proton-Translocating ATPases/physiology[MESH]Lysosomal ion channels involved in cellular entry and uncoating of env(epmc).pdf DeepDyve Pubget Overpricing