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10.1016/j.bbrc.2021.01.073 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2021.01.073 33515911!7825866!33515911     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33515911&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2021 ; 543 (ä): 45-49 Nephropedia Template TP {{tp|p=33515911|t=2021. The Nucleocapsid protein triggers the main humoral immune response in COVID-19 patients |pdf=|usr=}}{{33515911}} gab.com Text The Nucleocapsid protein triggers the main humoral immune response in COVID-19 patients JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33515911 #FOAvip In order to control the COVID-19 pandemic caused by SARS-CoV-2 infection, serious progress has been made to identify infected patients and to detect patients with a positive immune response against the virus. Currently, attempts to generate a vaccine against the coronavirus are ongoing. To understand SARS-CoV-2 immunoreactivity, we compared the IgG antibody response against SARS-CoV-2 in infected versus control patients by dot blot using recombinant viral particle proteins: N (Nucleocapsid), M (Membrane) and S (Spike). In addition, we used different protein fragments of the N and S protein to map immune epitopes. Most of the COVID-19 patients presented a specific immune response against the full length and fragments of the N protein and, to lesser extent, against a fragment containing amino acids 300-685 of the S protein. In contrast, immunoreactivity against other S protein fragments or the M protein was low. This response is specific for COVID-19 patients as very few of the control patients displayed immunoreactivity, likely reflecting an immune response against other coronaviruses. Altogether, our results may help develop method(s) for measuring COVID-19 antibody response, selectivity of methods detecting such SARS-CoV-2 antibodies and vaccine development. Twit Text FOAVip The Nucleocapsid protein triggers the main humoral immune response in COVID-19 patients ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33515911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33515911 #FOAvip English Wikipedia <ref>{{Cite pmid|33515911}}</ref> The Nucleocapsid protein triggers the main humoral immune response in COVID-19 patients #MMPMID33515911 Smits VAJ; Hernandez-Carralero E; Paz-Cabrera MC; Cabrera E; Hernandez-Reyes Y; Hernandez-Fernaud JR; Gillespie DA; Salido E; Hernandez-Porto M; Freire R Biochem Biophys Res Commun 2021[Mar]; 543 (ä): 45-49 PMID33515911show ga In order to control the COVID-19 pandemic caused by SARS-CoV-2 infection, serious progress has been made to identify infected patients and to detect patients with a positive immune response against the virus. Currently, attempts to generate a vaccine against the coronavirus are ongoing. To understand SARS-CoV-2 immunoreactivity, we compared the IgG antibody response against SARS-CoV-2 in infected versus control patients by dot blot using recombinant viral particle proteins: N (Nucleocapsid), M (Membrane) and S (Spike). In addition, we used different protein fragments of the N and S protein to map immune epitopes. Most of the COVID-19 patients presented a specific immune response against the full length and fragments of the N protein and, to lesser extent, against a fragment containing amino acids 300-685 of the S protein. In contrast, immunoreactivity against other S protein fragments or the M protein was low. This response is specific for COVID-19 patients as very few of the control patients displayed immunoreactivity, likely reflecting an immune response against other coronaviruses. Altogether, our results may help develop method(s) for measuring COVID-19 antibody response, selectivity of methods detecting such SARS-CoV-2 antibodies and vaccine development. |COVID-19/*immunology[MESH] |Coronavirus M Proteins/genetics/immunology[MESH] |Coronavirus Nucleocapsid Proteins/genetics/*immunology[MESH] |Humans[MESH] |Immune Sera/immunology[MESH] |Immunity, Humoral[MESH] |Immunoblotting[MESH] |Immunoglobulin G/blood[MESH] |Phosphoproteins/genetics/immunology[MESH] |SARS-CoV-2/chemistry/*immunology[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH]The Nucleocapsid protein triggers the main humoral immune response in (epmc).pdf DeepDyve Pubget Overpricing