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10.1007/s00296-021-04792-9

http://scihub22266oqcxt.onion/10.1007/s00296-021-04792-9
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33515320!7846902!33515320
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suck abstract from ncbi


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pmid33515320      Rheumatol+Int 2021 ; 41 (3): 509-518
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  • SARS-CoV-2 vaccines and autoimmune diseases amidst the COVID-19 crisis #MMPMID33515320
  • Velikova T; Georgiev T
  • Rheumatol Int 2021[Mar]; 41 (3): 509-518 PMID33515320show ga
  • Coronavirus disease 2019 (COVID-19) pandemic has become challenging even for the most durable healthcare systems. It seems that vaccination, one of the most effective public-health interventions, presents a ray of hope to end the pandemic by achieving herd immunity. In this review, we aimed to cover aspects of the current knowledge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and vaccine candidates in the light of autoimmune inflammatory diseases (AIIDs) and to analyze their potential in terms of safety and effectiveness in patients with AIIDs. Therefore, a focused narrative review was carried out to predict the possible implications of different types of SARS-CoV-2 vaccines which confer distinct immune mechanisms to establish immune response and protection against COVID-19: whole virus (inactivated or weakened), viral vector (replicating and non-replicating), nucleic acid (RNA, DNA), and protein-based (protein subunit, virus-like particle). Still, there is uncertainty among patients with AIIDs and clinicians about the effectiveness and safety of the new vaccines. There are a variety of approaches towards building a protective immunity against SARS-CoV-2. Only high-quality clinical trials would clarify the underlying immunological mechanisms of the newly implemented vaccines/adjuvants in patients living with AIIDs.
  • |Autoimmune Diseases/epidemiology/*immunology[MESH]
  • |COVID-19 Vaccines/adverse effects/*classification[MESH]
  • |COVID-19/epidemiology/*prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Risk Assessment[MESH]


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