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10.1007/s00253-021-11094-4 http://scihub22266oqcxt.onion/10.1007/s00253-021-11094-4 33515285!7847229!33515285     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Appl+Microbiol+Biotechnol 2021 ; 105 (4): 1333-1343 Nephropedia Template TP {{tp|p=33515285|t=2021. Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story |pdf=|usr=}}{{33515285}} gab.com Text Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story JO: Appl Microbiol Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=33515285 #FOAvip The anti-malarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been suggested as promising agents against the new coronavirus SARS-CoV-2 that induces COVID-19 and as a possible therapy for shortening the duration of the viral disease. The antiviral effects of CQ and HCQ have been demonstrated in vitro due to their ability to block viruses like coronavirus SARS in cell culture. CQ and HCQ have been proposed to reduce immune reactions to infectious agents, inhibit pneumonia exacerbation, and improve lung imaging investigations. CQ analogs have also revealed the anti-inflammatory and immunomodulatory effects in treating viral infections and related ailments. There was, moreover, convincing evidence from early trials in China about the efficacy of CQ and HCQ in the anti-COVID-19 procedure. Since then, research and studies have been massive to ascertain these drugs' efficacy and safety in treating the viral disease. In the present review, we construct a synopsis of the main properties and current data concerning the metabolism of CQ/HCQ, which were the basis of assessing their potential therapeutic roles against the new coronavirus infection. The effective role of QC and HCQ in the prophylaxis and therapy of COVID-19 infection is discussed in light of the latest international medical-scientific research results. KEY POINTS: * Data concerning metabolism and properties of CQ/HCQ are discussed. * The efficacy of CQ/HCQ against COVID-19 has been the subject of contradictory results. * CQ/HCQ has little or no effect in reducing mortality in SARS-CoV-2-affected patients. Twit Text FOAVip Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story ????Appl Microbiol Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=33515285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33515285 #FOAvip English Wikipedia <ref>{{Cite pmid|33515285}}</ref> Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story #MMPMID33515285 Gasmi A; Peana M; Noor S; Lysiuk R; Menzel A; Gasmi Benahmed A; Bjorklund G Appl Microbiol Biotechnol 2021[Feb]; 105 (4): 1333-1343 PMID33515285show ga The anti-malarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been suggested as promising agents against the new coronavirus SARS-CoV-2 that induces COVID-19 and as a possible therapy for shortening the duration of the viral disease. The antiviral effects of CQ and HCQ have been demonstrated in vitro due to their ability to block viruses like coronavirus SARS in cell culture. CQ and HCQ have been proposed to reduce immune reactions to infectious agents, inhibit pneumonia exacerbation, and improve lung imaging investigations. CQ analogs have also revealed the anti-inflammatory and immunomodulatory effects in treating viral infections and related ailments. There was, moreover, convincing evidence from early trials in China about the efficacy of CQ and HCQ in the anti-COVID-19 procedure. Since then, research and studies have been massive to ascertain these drugs' efficacy and safety in treating the viral disease. In the present review, we construct a synopsis of the main properties and current data concerning the metabolism of CQ/HCQ, which were the basis of assessing their potential therapeutic roles against the new coronavirus infection. The effective role of QC and HCQ in the prophylaxis and therapy of COVID-19 infection is discussed in light of the latest international medical-scientific research results. KEY POINTS: * Data concerning metabolism and properties of CQ/HCQ are discussed. * The efficacy of CQ/HCQ against COVID-19 has been the subject of contradictory results. * CQ/HCQ has little or no effect in reducing mortality in SARS-CoV-2-affected patients. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Antimalarials/chemistry/*therapeutic use[MESH] |Antiviral Agents/chemistry/*therapeutic use[MESH] |Chloroquine/chemistry/*therapeutic use[MESH] |Humans[MESH]Chloroquine and hydroxychloroquine in the treatment of COVID-19: the n(epmc).pdf DeepDyve Pubget Overpricing