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10.1093/ajcn/nqaa381

http://scihub22266oqcxt.onion/10.1093/ajcn/nqaa381
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33515005!7929381!33515005
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suck abstract from ncbi


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pmid33515005      Am+J+Clin+Nutr 2021 ; 113 (5): 1275-1281
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  • Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK Biobank #MMPMID33515005
  • Ma H; Zhou T; Heianza Y; Qi L
  • Am J Clin Nutr 2021[May]; 113 (5): 1275-1281 PMID33515005show ga
  • BACKGROUND: Previous studies have related vitamin D supplementation to a lower risk of acute respiratory tract infection. Emerging evidence suggests that vitamin D insufficiency is related to a higher risk of coronavirus disease 2019 (COVID-19) infection. OBJECTIVES: We aimed to investigate the prospective association between habitual use of vitamin D supplements and risk of COVID-19 infection, and assess whether such an association differed according to the different levels of circulating and genetically predicted vitamin D. METHODS: This study included 8297 adults who have records of COVID-19 test results from UK Biobank (from 16 March 2020 to 29 June 2020). The use of vitamin D supplements, circulating vitamin D levels, and main covariates were measured at baseline (2006-2010). Genetically predicted vitamin D levels were evaluated by genetic risk score. RESULTS: After adjustment for covariates, the habitual use of vitamin D supplements was significantly associated with a 34% lower risk of COVID-19 infection (OR, 0.66; 95% CI, 0.45-0.97; P = 0.034). Circulating vitamin D levels at baseline or genetically predicted vitamin D levels were not associated with the risk of COVID-19 infection. The association between the use of vitamin D supplements and the risk of COVID-19 infection did not vary according to the different levels of circulating or genetically predicted vitamin D (P-interactions = 0.75 and 0.74, respectively). CONCLUSIONS: Our findings suggest that habitual use of vitamin D supplements is related to a lower risk of COVID-19 infection, although we cannot rule out the possibility that the inverse association is due to residual confounding or selection bias. Further clinical trials are needed to verify these results.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Blood Group Antigens[MESH]
  • |COVID-19/complications/*epidemiology[MESH]
  • |Dietary Supplements[MESH]
  • |Educational Status[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Life Style[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Odds Ratio[MESH]
  • |Prospective Studies[MESH]
  • |Risk Factors[MESH]
  • |Socioeconomic Factors[MESH]
  • |Vitamin D/*administration & dosage[MESH]


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