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10.1089/mab.2020.0041

http://scihub22266oqcxt.onion/10.1089/mab.2020.0041
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33513050!ä!33513050

suck abstract from ncbi


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pmid33513050      Monoclon+Antib+Immunodiagn+Immunother 2021 ; 40 (1): 17-20
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  • How IvIg Can Mitigate Covid-19 Disease: A Symmetrical Immune Network Model #MMPMID33513050
  • Kohler H; Kaveri S
  • Monoclon Antib Immunodiagn Immunother 2021[Feb]; 40 (1): 17-20 PMID33513050show ga
  • In this report we provide a hypothesis of how intravenous immunoglobulin (IvIg) (pooled therapeutic normal IgG) mitigates the severe disease after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The disease is caused by an overreaction of the innate immune system producing a cytokine storm and inflicting multiple organ damage. Our interpretation of IvIg therapy hinges on a recent analysis of the immune dysregulation in Covid-19 infection. Previous infections with common cold coronavirus induce suppressor memory B cells that inhibit an immune response to Covid-19. The repertoire of natural antibodies (IvIg) contains suppressing antibodies in a symmetrically balanced network structure. When this repertoire interacts with the imbalanced network in the infected patient, it can neutralize the suppression of an antibody response against Covid-19. The described scenario for IvIg in Covid-19 infection may also apply in the therapy of autoimmune diseases.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Models, Immunological[MESH]
  • |Adaptive Immunity[MESH]
  • |COVID-19/*immunology[MESH]
  • |Cytokine Release Syndrome/immunology/prevention & control[MESH]
  • |Humans[MESH]
  • |Immunoglobulins, Intravenous/*therapeutic use[MESH]


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